CAJ | 학술논문

补体系统作为机体重要的免疫效应及其链式放大系统，是连接固有免疫和适应性免疫的重要桥梁，同时作为机体免疫调控网络的重要环节，在维持机体免疫自稳方面发挥重要作用。有文献已报道补体系统中有多种成分缺陷及补体的数量和质量存在异常的个体通常对某些疾病的易感性增加或直接导致相关疾病的发生，该文对目前常见的补体缺陷及其参与相关疾病发病机制的研究进展作一综述，期望为疾病的实验诊断提供新的思路。
보체계통작위궤체중요적면역효응급기련식방대계통，시련접고유면역화괄응성면역적중요교량，동시작위궤체면역조공망락적중요배절，재유지궤체면역자은방면발휘중요작용。유문헌이보도보체계통중유다충성분결함급보체적수량화질량존재이상적개체통상대모사질병적역감성증가혹직접도치상관질병적발생，해문대목전상견적보체결함급기삼여상관질병발병궤제적연구진전작일종술，기망위질병적실험진단제공신적사로。
Complement system,which has the characteristics of crucial immune responses and cascade reactions, not only has a crucial role in acting as a bridge between innate and adaptive immunities,but also is a part of immune regulatory network,and has important significance in the preservation of immunological homeostasis.Early studies introduced complement component deficiency.The abnormal quality and quantity of complement suggest that complement deficiency is associated with an increasing prevalence of infections and autoimmune diseases.This paper reviews the current common complement deficiencies and their associated diseases,expecting to provide new thoughts for the laboratory diagnosis of diseases.