中国执业药师
中國執業藥師
중국집업약사
CHINA LICENSED PHARMACIST
2015年
2期
25-27,45
,共4页
黄芩%连翘%黄连%金银花%广泛耐药铜绿假单胞菌%体外抑菌试验
黃芩%連翹%黃連%金銀花%廣汎耐藥銅綠假單胞菌%體外抑菌試驗
황금%련교%황련%금은화%엄범내약동록가단포균%체외억균시험
Scutellaria%Forsythia%Coptis%Honeysuckle%Extensively Drug-resistant Pseudomonas Aeruginosa%in Vitro Antibacterial Test
目的：探讨黄芩等4种中药对广泛耐药铜绿假单胞菌的抑菌作用。方法：采用中药抗菌试验试管法测定药物的最低抑菌浓度（MIC）。结果：黄芩、连翘、黄连、金银花对30株广泛耐药铜绿假单胞菌有不同程度的体外抑菌作用， MIC均值分别为475.00，345.83，60.94，379.17 mg/mL ，与标准菌株ATCC27853的MIC相近。其中黄连的抑菌作用最强。结论：4种中草药对30株广泛耐药铜绿假单胞菌均有不同程度的抑菌作用，本地与外地收集的菌株，抑菌作用无显著性差异（P >0.05）。
目的：探討黃芩等4種中藥對廣汎耐藥銅綠假單胞菌的抑菌作用。方法：採用中藥抗菌試驗試管法測定藥物的最低抑菌濃度（MIC）。結果：黃芩、連翹、黃連、金銀花對30株廣汎耐藥銅綠假單胞菌有不同程度的體外抑菌作用， MIC均值分彆為475.00，345.83，60.94，379.17 mg/mL ，與標準菌株ATCC27853的MIC相近。其中黃連的抑菌作用最彊。結論：4種中草藥對30株廣汎耐藥銅綠假單胞菌均有不同程度的抑菌作用，本地與外地收集的菌株，抑菌作用無顯著性差異（P >0.05）。
목적：탐토황금등4충중약대엄범내약동록가단포균적억균작용。방법：채용중약항균시험시관법측정약물적최저억균농도（MIC）。결과：황금、련교、황련、금은화대30주엄범내약동록가단포균유불동정도적체외억균작용， MIC균치분별위475.00，345.83，60.94，379.17 mg/mL ，여표준균주ATCC27853적MIC상근。기중황련적억균작용최강。결론：4충중초약대30주엄범내약동록가단포균균유불동정도적억균작용，본지여외지수집적균주，억균작용무현저성차이（P >0.05）。
Objective:To evaluate bacteriostatic effects of four kinds of Chinese herbal medicines , including baicalin , on the extensively drug-resistant Pseudomonas aeruginosa . Methods: The antibacterial medicine test tube method for TCM was adopted to determine the minimum inhibitory concentration ( MIC ) of the tested drug . Re-sults:Scutellaria , Forsythia , Coptis and Honeysuckle showed a different degree of bacteriostatic effect in vitro an-tibacterial test on 30 strains of extensively drug-resistant Pseudomonas aeruginosa . The MIC mean value was 475 . 00 , 345 . 83 , 60 . 94 and 379 . 17 mg/mL respectively , which was similar to the MIC of the standard strain ATCC27853 , and Coptis chinensis showed the strongest inhibitory effect . Conclusion: Four kinds of Chinese herbal medicines had different antibacterial effects on 30 strains of extensively drug-resistant Pseudomonas aeruginosa , and there was no significant difference of bacteriostasis ( P > 0 . 05 ) between the strains collected locally and from other places .
