CAJ | 학술논문

microRNA是一类长度为19～25个核苷酸的内源性非编码小分子RNA，通过抑制靶基因的表达参与包括细胞增殖、分化、凋亡、炎症调节、干细胞发育等几乎所有重要的生物学过程，许多microRNA在肿瘤细胞中异常表达，提示可能与肿瘤的发生发展有关。急性淋巴细胞性白血病（ALL）是最常见的儿童肿瘤，临床表现、形态学、免疫表型及遗传学特征极具异质性。现已发现若干microRNA在ALL中异常表达，且与其生物学特性以及临床特征、预后和治疗相关。对microRNA的了解有助于帮助人们更深入地认识ALL的发病机理，有助于在寻找合适的诊断、判定预后的分子标志物以及潜在的治疗靶点方面取得新突破。
microRNA시일류장도위19～25개핵감산적내원성비편마소분자RNA，통과억제파기인적표체삼여포괄세포증식、분화、조망、염증조절、간세포발육등궤호소유중요적생물학과정，허다microRNA재종류세포중이상표체，제시가능여종류적발생발전유관。급성림파세포성백혈병（ALL）시최상견적인동종류，림상표현、형태학、면역표형급유전학특정겁구이질성。현이발현약간microRNA재ALL중이상표체，차여기생물학특성이급림상특정、예후화치료상관。대microRNA적료해유조우방조인문경심입지인식ALL적발병궤리，유조우재심조합괄적진단、판정예후적분자표지물이급잠재적치료파점방면취득신돌파。
MicroRNA is a type of endogenous noncoding small molecular RNA with a length of 19-25 nucleotides. MicroRNAs are involved in almost all key biological processes, such as cell proliferation, differentiation, apoptosis, and hematopoiesis, via repres-sion of target gene expression. Acute lymphoblastic leukemia (ALL) is the most common type of pediatric cancer. It is a heterogeneous disease with different clinical signs, morphology, immunophenotype, and cytogenetics. Currently, several microRNAs have implicated aberrant expression in ALL and play an important role in cancer initiation and development. MicroRNA expression pattern is associated with clinical feature, prognosis, and treatment. Therefore, microRNAs could act as a novel marker to help scientists learn about the pathogenesis of ALL and to provide more effective treatment options.