CAJ | 학술논문

目的：探讨套细胞淋巴瘤（mantle cell lymphoma，MCL）的临床病理特点。方法：收集112例MCL的临床及病理资料，采用免疫组织化学（Envision二步法）行相关抗体标记，荧光原位杂交技术（fluorescence in situ hybridization，FISH）对其中24例作IgH/CCND1基因断裂检测。结果：112例（包括2例多形性和母细胞变亚型）均表达B细胞相关抗原，94.6%（106/112）表达cy?clinD1，92.9%（104/112）表达CD5。不同免疫表型的经典型MCL的Ki-67及平均生存期无统计学差异（P>0.05）。3例CD5-的MCL未检测出IgH/CCND1基因断裂，2例经典型MCL检测出IgH/CCND1多倍体。结论：MCL是一种具有特殊免疫表型的B细胞淋巴瘤，多形性及母细胞变异型的预后较差，对特殊亚型的MCL诊断有必要细分。
목적：탐토투세포림파류（mantle cell lymphoma，MCL）적림상병리특점。방법：수집112례MCL적림상급병리자료，채용면역조직화학（Envision이보법）행상관항체표기，형광원위잡교기술（fluorescence in situ hybridization，FISH）대기중24례작IgH/CCND1기인단렬검측。결과：112례（포괄2례다형성화모세포변아형）균표체B세포상관항원，94.6%（106/112）표체cy?clinD1，92.9%（104/112）표체CD5。불동면역표형적경전형MCL적Ki-67급평균생존기무통계학차이（P>0.05）。3례CD5-적MCL미검측출IgH/CCND1기인단렬，2례경전형MCL검측출IgH/CCND1다배체。결론：MCL시일충구유특수면역표형적B세포림파류，다형성급모세포변이형적예후교차，대특수아형적MCL진단유필요세분。
Objective:To explore the clinicopathologic features of 112 patients with mantle cell lymphoma (MCL). Methods:Da-ta from 112 MCL cases were collected, and immunohistochemical assay was conducted. A break in the CCND1 gene was detected by fluorescence in situ hybridization (FISH). The t-test was used in the statistical analysis. Results:All tumor cells in the 112 cases ex-pressed B cell-related antigen, including 1 blastoid subtype and 1 polymorphic subtype. Among all the cases, 106 expressed CD5 and 104 expressed cyclinD1. A break in the CCND1 gene was not found in 3 cases with CD5-MCL. IgH/CCND1 polyploid was found in 2 classical cases. Conclusion:MCL is a type of special immunophenotypic B-cell lymphoma. The prognoses of blastoid and polymorphic subtypes are poor. Special subtypes should be classified during diagnosis.