CAJ | 학술논문

磷脂酰丝氨酸(Phosphatidylserine, PS)是细胞质膜重要的磷脂成分之一，具有重要的生物学功能。在细胞凋亡及一些特殊的病理条件下，细胞内 ATP 供能不足，胞浆 Ca2+浓度升高，引起 PS 发生外翻。PS 外翻在不同类型细胞中具有不同的生物学功能，且外翻的程度与疾病发展程度密切相关，可作为癌症等多种疾病治疗的靶标。文章综述了细胞质膜中磷脂酰丝氨酸的重要生物学功能和意义、磷脂酰丝氨酸外翻的分子机制及在临床医学方面的应用，以期对未来的功能和临床应用研究提供参考。
린지선사안산(Phosphatidylserine, PS)시세포질막중요적린지성분지일，구유중요적생물학공능。재세포조망급일사특수적병리조건하，세포내 ATP 공능불족，포장 Ca2+농도승고，인기 PS 발생외번。PS 외번재불동류형세포중구유불동적생물학공능，차외번적정도여질병발전정도밀절상관，가작위암증등다충질병치료적파표。문장종술료세포질막중린지선사안산적중요생물학공능화의의、린지선사안산외번적분자궤제급재림상의학방면적응용，이기대미래적공능화림상응용연구제공삼고。
Phosphatidylserine (PS), one important phospholipid of cell membranes, has crucial biological functions. Under special pathological circumstances such as cell apoptosis, cells cannot generate enough ATP for energy and the concentration of cytoplasmic Ca2+ increases, resulting in PS eversion. PS eversion has different biological func-tions in different cell types. In addition, the degree of eversion is closely associated with the progress of diseases. Therefore, it can be therapeutic targets of cancer and many other diseases. In this review, we summarize the funda-mental biological functions of PS, molecular mechanisms of PS eversion, as well as its potential in translational medicine.