温州医科大学学报
溫州醫科大學學報
온주의과대학학보
Journal of Wenzhou Medical University
2015年
2期
100-105
,共6页
张晓燕%杨闯%梁艳%林海西%杜松妹%王维千%陈宏%赵永忠%王欣%刘惠茹%王美豪%陈庆建%唐闻捷
張曉燕%楊闖%樑豔%林海西%杜鬆妹%王維韆%陳宏%趙永忠%王訢%劉惠茹%王美豪%陳慶建%唐聞捷
장효연%양틈%량염%림해서%두송매%왕유천%진굉%조영충%왕흔%류혜여%왕미호%진경건%당문첩
注意缺陷多动障碍%分型%静息态脑功能%磁共振,功能
註意缺陷多動障礙%分型%靜息態腦功能%磁共振,功能
주의결함다동장애%분형%정식태뇌공능%자공진,공능
attention deifcit hyperactivity disorder%subtype%amplitude of low frequency lfuctuation%fMRI
目的：比较儿童注意缺陷多动障碍（ADHD）亚型间脑低频振荡振幅（ALFF）差异以及静息态ALFF与行为学的相关性。方法：使用磁共振扫描仪对78例儿童进行脑功能磁共振静息状态扫描，其中ADHD患者43例（ADHD-I组15例，ADHD-C组28例），正常对照组35例。采用ALFF评估静息态脑功能，Conners儿童行为问卷评估行为现状。结果：ADHD-I组在左额下回、右楔前叶等脑区ALFF值低于正常对照组，差异有统计学意义（P＜0.05）；ADHD-C组的左额中回、右楔前叶、右边缘叶扣带回等脑区ALFF值低于正常对照，差异有统计学意义（P＜0.05）；ADHD-C组在右枕叶楔状叶、双侧颞叶、左侧扣带回等多个脑区ALFF值低于ADHD-I组，差异有统计学意义（P＜0.05）。额颞叶、小脑的一些脑区的静息态ALFF值与患者的多动指数有关，差异有统计学意义（P＜0.05）。结论：多个脑区的静息态ALFF值在不同亚型间存在显著差异。
目的：比較兒童註意缺陷多動障礙（ADHD）亞型間腦低頻振盪振幅（ALFF）差異以及靜息態ALFF與行為學的相關性。方法：使用磁共振掃描儀對78例兒童進行腦功能磁共振靜息狀態掃描，其中ADHD患者43例（ADHD-I組15例，ADHD-C組28例），正常對照組35例。採用ALFF評估靜息態腦功能，Conners兒童行為問捲評估行為現狀。結果：ADHD-I組在左額下迴、右楔前葉等腦區ALFF值低于正常對照組，差異有統計學意義（P＜0.05）；ADHD-C組的左額中迴、右楔前葉、右邊緣葉釦帶迴等腦區ALFF值低于正常對照，差異有統計學意義（P＜0.05）；ADHD-C組在右枕葉楔狀葉、雙側顳葉、左側釦帶迴等多箇腦區ALFF值低于ADHD-I組，差異有統計學意義（P＜0.05）。額顳葉、小腦的一些腦區的靜息態ALFF值與患者的多動指數有關，差異有統計學意義（P＜0.05）。結論：多箇腦區的靜息態ALFF值在不同亞型間存在顯著差異。
목적：비교인동주의결함다동장애（ADHD）아형간뇌저빈진탕진폭（ALFF）차이이급정식태ALFF여행위학적상관성。방법：사용자공진소묘의대78례인동진행뇌공능자공진정식상태소묘，기중ADHD환자43례（ADHD-I조15례，ADHD-C조28례），정상대조조35례。채용ALFF평고정식태뇌공능，Conners인동행위문권평고행위현상。결과：ADHD-I조재좌액하회、우설전협등뇌구ALFF치저우정상대조조，차이유통계학의의（P＜0.05）；ADHD-C조적좌액중회、우설전협、우변연협구대회등뇌구ALFF치저우정상대조，차이유통계학의의（P＜0.05）；ADHD-C조재우침협설상협、쌍측섭협、좌측구대회등다개뇌구ALFF치저우ADHD-I조，차이유통계학의의（P＜0.05）。액섭협、소뇌적일사뇌구적정식태ALFF치여환자적다동지수유관，차이유통계학의의（P＜0.05）。결론：다개뇌구적정식태ALFF치재불동아형간존재현저차이。
Objective:To study the different activities of amplitude of low frequency lfuctuation (ALFF) among attention deficit hyperactivity disorder (ADHD) subtypes and the correlation between ALFF and be-haviors. Methods:Seventy-eight participants were checked up by resting state functional magnetic resonance scanner, including 43 ADHD patients (15 of ADHD-I and 28 of ADHD-C) and 35 non-ADHD controls. The amplitude of low frequency fluctuation (ALFF) approach was used to analyse the brain function in resting state, and Conners children’s behavior scale was used to assess the behavior actuality. Results:Compared with the normal controls, ADHD-I showed decreased ALFF in left inferior frontal gyrus, right precuneus, and etc;ADHD-C showed decreased ALFF in left middle frontal gyrus, right precuneus, bilateral limbic lobe cingulate gyrus, and etc;and compared with ADHD-I, ADHD-C showed decreased ALFF in right cuneus, bilateral tem-poral lobe, limbic lobe cingulate gyrus, and etc. There were many brain regions of frontal/temporal lobe and cerebellum were correlated with Conners Index of Hyperactivity. All of the differences were statistically sig-niifcant (P<0.05). Conclusion:Amplitude of low frequency lfuctuation (ALFF) values of many brain regions were different among ADHD subtypes in rs-fMRI, and most of which were correlated with Conners Index of Hyperactivity.
