CAJ | 학술논문

目的：探讨CD44v6和Ezrin在大肠腺瘤癌变中的表达及其与临床病理指标和预后的关系。方法：应用免疫组化检测CD44v6和Ezrin蛋白在大肠腺癌(80例)、腺瘤伴低级别上皮内瘤变(40例)、腺瘤伴高级别上皮内瘤变(20例)及正常黏膜(20例)中的表达，分析其表达与临床病理指标及生存时间的关系。结果：CD44v6和Ezrin在腺瘤伴高级别上皮内瘤变和腺癌组的表达高于正常黏膜及腺瘤伴低级别上皮内瘤变组，差别有统计学意义(P均<0.05)。二者在淋巴结有转移组、有浆膜层浸润组、III~IV期的表达分别高于淋巴结无转移组、无浆膜层浸润组及I~II期，差别均有统计学意义(P均<0.05)。CD44v6和Ezrin表达与患者生存时间相关(Log-rank=18.587，P<0.05；Log-rank=7.804，P<0.05)。Cox回归多因素分析显示CD44v6是独立的预后危险因素(HR：7.582，95%CI：1.605~35.815，P=0.011)。结论：CD44v6和Ezrin的表达与大肠腺瘤癌变、浸润和转移相关，联合检测CD44v6和Ezrin的表达对判断大肠腺瘤癌变及预后具有参考价值。
목적：탐토CD44v6화Ezrin재대장선류암변중적표체급기여림상병리지표화예후적관계。방법：응용면역조화검측CD44v6화Ezrin단백재대장선암(80례)、선류반저급별상피내류변(40례)、선류반고급별상피내류변(20례)급정상점막(20례)중적표체，분석기표체여림상병리지표급생존시간적관계。결과：CD44v6화Ezrin재선류반고급별상피내류변화선암조적표체고우정상점막급선류반저급별상피내류변조，차별유통계학의의(P균<0.05)。이자재림파결유전이조、유장막층침윤조、III~IV기적표체분별고우림파결무전이조、무장막층침윤조급I~II기，차별균유통계학의의(P균<0.05)。CD44v6화Ezrin표체여환자생존시간상관(Log-rank=18.587，P<0.05；Log-rank=7.804，P<0.05)。Cox회귀다인소분석현시CD44v6시독립적예후위험인소(HR：7.582，95%CI：1.605~35.815，P=0.011)。결론：CD44v6화Ezrin적표체여대장선류암변、침윤화전이상관，연합검측CD44v6화Ezrin적표체대판단대장선류암변급예후구유삼고개치。
OBJECTIVE:We explored the expressionsofCD44v6 andEzrin in colorectal adenoma carcinogenesis and their correlations with clinicopathological factors and prognosis. METHODS:Immunohistochemistry for CD44v6 and Ezrin were performed in normal mucosa(20 cases),low grade adenoma tissues(40 cases) ,high grades adenoma tissues(20 cases)and colorectal cancer(80 cases). The correlations between expressions of CD44v6 and Ezrin with survival time and clinicopathological factors were evaluated.RESULTS:Expressions of CD44v6 and Ezrin in high grades colorectal adenomas and adenocarcinoma groups were higher than normal mucosa and low grade colorectal adenoma groups(P<0.01). Expressions were higher in lymph node metastasis group,serosal infiltration group,stages III-IV group than no lymph node metastasis group,no serosal infiltration and stages I-II group. CD44v6 and Ezrin were significantly correlated with survival time(Log-rank=18.587,P<0.05;Log-rank=7.804,P<0.05). Cox regression analysis showed that CD44v6 was an independent risk factor for prognosis (HR:7.582,95%CI:1.605-35.815,P=0.011).CONCLUSION:The expressions of CD44v6 and Ezrin were correlated with process of colorectal adenoma-carcinoma transition,invasion and metastasis. It would be valuable to c ombine C D44v6 a nd E zrin t o p redict m alignant t ransformation o f c olorectal a denoma a nd p rognosis.