医学临床研究
醫學臨床研究
의학림상연구
JOURNAL OF CLINICAL RESEARCH
2015年
1期
70-72
,共3页
白细胞L1抗原复合物/血液%心肌梗死%急性病%预后
白細胞L1抗原複閤物/血液%心肌梗死%急性病%預後
백세포L1항원복합물/혈액%심기경사%급성병%예후
Leukocyte L1 Antigen Complex/BL%Myocardial Infarction%Acute Disease%Progno-sis
目的探讨钙卫蛋白（S100A8／A9）在急性心肌梗死（Acute myocardial infarction ，AMI）患者血清中的水平以及与患者近期预后的关系。方法收集2012年3月至2013年3月在本院诊治且病历资料完整的AMI患者64例，稳定型心绞痛（SAP组）30例，另选择健康体检者（NC组）30例作为对照组。收集研究对象的一般情况，血生化指标；检测各组入院时空腹血清S100A8／A9水平，出院后3个月对AM I患者进行电话随访，了解患者的近期预后。结果 AMI组的血清S100A8／A9水平明显高于 SAP组、健康对照组（ P ＜0．05）；SAP组S100A8／A9水平亦高于健康对照组（ P ＜0．05）；S100A8／A9、空腹血糖（FPG）、吸烟以及高胆固醇血症影响 AMI患者的近期预后（死亡或因心脏事件再住院）（ P ＜0．05）。结论 AMI患者血清S100A8／A9水平显著升高；血清S100A8／A9与AMI患者的近期预后相关。
目的探討鈣衛蛋白（S100A8／A9）在急性心肌梗死（Acute myocardial infarction ，AMI）患者血清中的水平以及與患者近期預後的關繫。方法收集2012年3月至2013年3月在本院診治且病歷資料完整的AMI患者64例，穩定型心絞痛（SAP組）30例，另選擇健康體檢者（NC組）30例作為對照組。收集研究對象的一般情況，血生化指標；檢測各組入院時空腹血清S100A8／A9水平，齣院後3箇月對AM I患者進行電話隨訪，瞭解患者的近期預後。結果 AMI組的血清S100A8／A9水平明顯高于 SAP組、健康對照組（ P ＜0．05）；SAP組S100A8／A9水平亦高于健康對照組（ P ＜0．05）；S100A8／A9、空腹血糖（FPG）、吸煙以及高膽固醇血癥影響 AMI患者的近期預後（死亡或因心髒事件再住院）（ P ＜0．05）。結論 AMI患者血清S100A8／A9水平顯著升高；血清S100A8／A9與AMI患者的近期預後相關。
목적탐토개위단백（S100A8／A9）재급성심기경사（Acute myocardial infarction ，AMI）환자혈청중적수평이급여환자근기예후적관계。방법수집2012년3월지2013년3월재본원진치차병력자료완정적AMI환자64례，은정형심교통（SAP조）30례，령선택건강체검자（NC조）30례작위대조조。수집연구대상적일반정황，혈생화지표；검측각조입원시공복혈청S100A8／A9수평，출원후3개월대AM I환자진행전화수방，료해환자적근기예후。결과 AMI조적혈청S100A8／A9수평명현고우 SAP조、건강대조조（ P ＜0．05）；SAP조S100A8／A9수평역고우건강대조조（ P ＜0．05）；S100A8／A9、공복혈당（FPG）、흡연이급고담고순혈증영향 AMI환자적근기예후（사망혹인심장사건재주원）（ P ＜0．05）。결론 AMI환자혈청S100A8／A9수평현저승고；혈청S100A8／A9여AMI환자적근기예후상관。
[Objective]To explore the correlation between serum calprotectin(S100A8/A9) and short‐term prognosis in patients with acute myocardial infarction(AMI) .[Methods]A total of 64 AMI patients and 30 pa‐tients with stable angina pectoris(SAP group) who had intact clinical data and diagnosed in our hospital from March 2012 to March 2013 were collected .Other 30 healthy subjects(NC) were chosen as control group .Gen‐eral condition and biochemical indicators of all subjects were collected .Serum level of fasting S100A8/A9 in each group at admission was detected .Patients with AMI at 3 months after discharge were followed up by phone so as to understand the short‐term prognosis of patients .[Results] Serum level of S100A8/A9 in AMI group was obviously higher than that in SAP group and healthy control group( P <0 .05) ,and that in SAP group was also higher than that in healthy control group( P <0 .05) .Short‐term prognosis(death or rehospi‐talization due to cardiac event) of patients with AMI was affected by S100A8/A9 ,FPG ,smoking and hyper‐cholesterolemia( P <0 .05) .[Conclusion]Serum level of S100A8/A9 in patients with AMI is significantly ele‐vated ,and related with the short‐term prognosis of patients with AMI .
