CAJ | 학술논문

目的探讨超敏C‐反应蛋白（hs‐CRP ）在颅咽管瘤肿瘤囊液及脑脊液、血清中的含量及意义。方法采用透射免疫比浊法和双抗体夹心ELISA法分别测定22例造釉细胞型颅咽管瘤和6例鳞状乳头型颅咽管瘤肿瘤囊液及脑脊液、血清中hs‐CRP含量，并对结果行统计学分析。结果造釉细胞型颅咽管瘤囊液及脑脊液、血清hs‐CRP含量分别为（42．81±8．96）×105 pg／mL、（0．35±0．06）×105 pg／mL、（17．23±5．45）×105 pg／mL ，鳞状乳头型颅咽管瘤囊液及脑脊液、血清hs‐CRP含量分别为（34．25±9．88）×105 pg／mL、（0．34±0．06）×105 pg／mL、（16．07±9．47）×105 pg／mL。颅咽管瘤囊液中hs‐CRP含量显著性高于脑脊液及血清中hs‐CRP含量（ P＜0．01），两种病理类型颅咽管瘤囊液及脑脊液、血清中hs‐CRP含量相比较差异无显著性（ P＞0．05）。结论颅咽管瘤肿瘤囊液中hs‐CRP含量相对脑脊液和血清显著增高，提示囊液中炎性物质刺激可能与肿瘤组织炎症有关；不同病理类型颅咽管瘤肿瘤囊液中hs‐CRP含量无显著性差异，不能以肿瘤囊液炎性程度解释不同病理类型颅咽管瘤组织炎症的差异性。
목적탐토초민C‐반응단백（hs‐CRP ）재로인관류종류낭액급뇌척액、혈청중적함량급의의。방법채용투사면역비탁법화쌍항체협심ELISA법분별측정22례조유세포형로인관류화6례린상유두형로인관류종류낭액급뇌척액、혈청중hs‐CRP함량，병대결과행통계학분석。결과조유세포형로인관류낭액급뇌척액、혈청hs‐CRP함량분별위（42．81±8．96）×105 pg／mL、（0．35±0．06）×105 pg／mL、（17．23±5．45）×105 pg／mL ，린상유두형로인관류낭액급뇌척액、혈청hs‐CRP함량분별위（34．25±9．88）×105 pg／mL、（0．34±0．06）×105 pg／mL、（16．07±9．47）×105 pg／mL。로인관류낭액중hs‐CRP함량현저성고우뇌척액급혈청중hs‐CRP함량（ P＜0．01），량충병리류형로인관류낭액급뇌척액、혈청중hs‐CRP함량상비교차이무현저성（ P＞0．05）。결론로인관류종류낭액중hs‐CRP함량상대뇌척액화혈청현저증고，제시낭액중염성물질자격가능여종류조직염증유관；불동병리류형로인관류종류낭액중hs‐CRP함량무현저성차이，불능이종류낭액염성정도해석불동병리류형로인관류조직염증적차이성。
[Objective]To explore the level of high‐sensitivity C‐reactive protein(hs‐CRP) in hydatid fluid , cerebrospinal fluid(CSF) and serum of craniopharyngioma and its significance .[Methods]Turbidimetry immu‐noassay and double‐antibody sandwich ELISA were used to measure the levels of hs‐CRP in hydatid fluid ,CSF and serum of 22 patients with ameloblast craniopharyngioma and 6 patients with squamous papillary cranio‐pharyngioma ,respectively .The results were analyzed by statistical method .[Results]The levels of hs‐CRP in hydatid fluid ,CSF and serum of ameloblast craniopharyngioma were (42 .81 ± 8 .96) × 105 pg/mL ,(0 .35 ± 0 .06)× 105 pg/mL and (17 .23 ± 5 .45)× 105 pg/mL respectively ,and those in squamous papillary craniophar‐yngioma were (34 .25 ± 9 .88)× 105 pg/mL ,(0 .34 ± 0 .06)× 105 pg/mL and (16 .07 ± 9 .47)× 105 pg/mL re‐spectively .The levels of hs‐CRP in hydatid fluid of craniopharyngioma were significantly higher than those in CSF and serum( P <0 .01) .There was no significant difference in hs‐CRP between two pathological types of craniopharyngioma( P >0 .05) .[Conclusion] The significantly higher level of hs‐CRP in hydatid fluid of cra‐niopharyngioma than that in cerebrospinal fluid and serum suggests that stimulation by inflammation sub‐stances in hydatid fluid may be related to the tumor tissue inflammation .There is no significant difference in hs‐CRP level of hydatid fluid among different pathological types of craniopharyngioma .It indicates that the in‐flammatory severity in tumor hydatid fluid can not explain the diversity of craniopharyngioma tissue inflamma‐tion with different pathological types .