CAJ | 학술논문

目的探讨局部免疫调节治疗结节性亚急性甲状腺炎的疗效。方法将112例诊断为结节性亚急性甲状腺炎的患者按不同治疗方法分为观察组（ n ＝59）和对照组（ n ＝53）。对照组采用口服泼尼松治疗，观察组采用甲状腺结节内局部注射曲安奈德治疗，治疗6个月后比较两组患者的疗效及实验室指标的变化。结果①观察组局部疼痛症状消失时间明显短于对照组[（7．3±2．7）dvs（21．1±5．2）d，P ＜0．01]，甲状腺结节消失时间亦短于对照组[（9．7±3．4）dvs（33．5±4．9）d，P ＜0．01]；②治疗6个月后的有效率（局部症状消失，结节消失）观察组为88．14％（52／59），对照组为47．17％（25／53），两者比较差异显著（ P＜0．01）；③治愈后随访12个月，注射组复发率15．4％（8／52）显著低于对照组28．0％（7／25）（ P ＜0．01）。结论结节性亚急性甲状腺炎曲安奈德局部注射治疗优于口服泼尼松。
목적탐토국부면역조절치료결절성아급성갑상선염적료효。방법장112례진단위결절성아급성갑상선염적환자안불동치료방법분위관찰조（ n ＝59）화대조조（ n ＝53）。대조조채용구복발니송치료，관찰조채용갑상선결절내국부주사곡안내덕치료，치료6개월후비교량조환자적료효급실험실지표적변화。결과①관찰조국부동통증상소실시간명현단우대조조[（7．3±2．7）dvs（21．1±5．2）d，P ＜0．01]，갑상선결절소실시간역단우대조조[（9．7±3．4）dvs（33．5±4．9）d，P ＜0．01]；②치료6개월후적유효솔（국부증상소실，결절소실）관찰조위88．14％（52／59），대조조위47．17％（25／53），량자비교차이현저（ P＜0．01）；③치유후수방12개월，주사조복발솔15．4％（8／52）현저저우대조조28．0％（7／25）（ P ＜0．01）。결론결절성아급성갑상선염곡안내덕국부주사치료우우구복발니송。
[Objective]To evaluate the therapeutic effect of local immune regulation on subacute thyroiditis pa‐tients (SAT ) with nodules .[Methods]A total of 112 nodular SAT patients were randomly divided into two groups .The control group received an oral dose of prednisone while the observation group had an intra‐thyroid nodule injection of triamcinolone acetonide . The effectiveness and recurrence rate were compared between two groups .And the changes of clinical efficacies and indicators were observed .[Results]The withdrawal time of local pain symptoms was significantly shorter in observation group than that in control group(7 .3 ± 2 .7 vs 21 .1 ± 5 .2 days ,P<0 .01) .The same results were observed for thyroid nodule disappearing time (9 .7 ± 3 .4 vs 33 .5 ± 4 .9 days ,P<0 .01) .The effectiveness after 6‐month treatment were 88 .14% (52/59)in observation group versus 47 .17% (25/53) in control group .During a follow‐up period of 12 months ,the recurrence rate was significantly lower in observation group than that in control group [15 .4% (8/52) vs 28 .0% (7/25) ,P<0 .01] .[Conclusion]For nodular SAT patients ,local immune treatment via an intra‐thyroid nodule injection of triamcinolone acetonide is superior to an oral dose of prednisone .