CAJ | 학술논문

目的：探求脑胶质瘤RUNX3的表达及生物学意义。方法手术切除脑胶质瘤标本55例相对制成石蜡组织微阵列，运用免疫组织化学方法检测RUNX3在上述55例癌灶和其中19例癌旁相对正常脑组织中的表达情况和分布特点，并分析其表达与患者临床病理特征之间的关系。结果胶质瘤中RUNX3蛋白表达率为38．2％（21／55）较相对正常脑组织中表达率94．7％（18／19）明显下降，差异有显著性意义（P＜0．05）。 RUNX3蛋白表达无性别、年龄及病理分级间差异，但在病灶直径≥3 cm及生存期＜3年的胶质瘤患者中，RUNX3蛋白表达显著低于病灶直径＜3 cm 及生存期＞3年的患者（P＜0．05）。 RUNX3在不同类型脑胶质瘤中呈现差异表达。结论RUNX3蛋白表达下调可能与胶质瘤进展及患者的预后有关。
목적：탐구뇌효질류RUNX3적표체급생물학의의。방법수술절제뇌효질류표본55례상대제성석사조직미진렬，운용면역조직화학방법검측RUNX3재상술55례암조화기중19례암방상대정상뇌조직중적표체정황화분포특점，병분석기표체여환자림상병리특정지간적관계。결과효질류중RUNX3단백표체솔위38．2％（21／55）교상대정상뇌조직중표체솔94．7％（18／19）명현하강，차이유현저성의의（P＜0．05）。 RUNX3단백표체무성별、년령급병리분급간차이，단재병조직경≥3 cm급생존기＜3년적효질류환자중，RUNX3단백표체현저저우병조직경＜3 cm 급생존기＞3년적환자（P＜0．05）。 RUNX3재불동류형뇌효질류중정현차이표체。결론RUNX3단백표체하조가능여효질류진전급환자적예후유관。
Objective To explore the expression characteristics and biological significance of RUNX3 in different glioma. Methods Surgically removed 19 relatively normal brain tissues and 55 glioma tissues were collected and embeded with par-affin to make tissue microarray using high-throughput tissue chip technology.Expression of RUNX3 in these tissues was detected by immunohistochemistry and the relationship between RUNX3 expression and clinical pathological features of glo-mia patients were analyzed.Results RUNX3 protein was highly expressed in relatively normal brain tissues (94.7%) com-pared to glioma tissues (38.2%, P<0.05).The RUNX3 expression was not obviously related to gender, age and patho-logic stage, but was statistically corelated with tumor size ( diameter≥3 cm) and patients'survival ( overall survival <3 years)(P<0.05) and the expression of RUNX3 was different in different types of glioma.Conclusion RUNX3 gene ex-pression is related to the tumor size and survival, which indicates important molecular events in glioma progression.