CAJ | 학술논문

目的：探讨文拉法辛联合丁螺环酮治疗难治性抑郁症的临床疗效和安全性。方法将60例难治性抑郁症患者随机分为两组，均口服文拉法辛治疗，联合组联合丁螺环酮治疗，观察4周。于治疗前后采用汉密顿抑郁量表评定临床疗效，副反应量表评定不良反应。结果治疗4周末联合组显效率为77．4％、有效率为87．1％，对照组分别为42．5％、85．0％，联合组显效率、有效率显著高于对照组（χ2＝13．02、5．01，P＜0．05或0．01）。两组不良反应较轻微，主要表现为恶心、出汗、头疼等。结论文拉法辛联合丁螺环酮治疗难治性抑郁症具有增效作用，疗效显著，起效快，不增加不良反应，显著优于单用文拉法辛治疗。
목적：탐토문랍법신연합정라배동치료난치성억욱증적림상료효화안전성。방법장60례난치성억욱증환자수궤분위량조，균구복문랍법신치료，연합조연합정라배동치료，관찰4주。우치료전후채용한밀돈억욱량표평정림상료효，부반응량표평정불량반응。결과치료4주말연합조현효솔위77．4％、유효솔위87．1％，대조조분별위42．5％、85．0％，연합조현효솔、유효솔현저고우대조조（χ2＝13．02、5．01，P＜0．05혹0．01）。량조불량반응교경미，주요표현위악심、출한、두동등。결논문랍법신연합정라배동치료난치성억욱증구유증효작용，료효현저，기효쾌，불증가불량반응，현저우우단용문랍법신치료。
Objective To explore the efficacy and safety of venlafaxine combined with buspirone in the treatment of treatment‐resistant depression (TRD) .Methods Sixty TRD patients were randomly divided into two groups both taking orally venlafaxine ,combination group was plus buspi‐rone for 4 weeks .Efficacies were assessed with the Hamilton Depression Scale (HAMD) before and after treatment and adverse reactions with the Treatment Emergent Symptom Scale (TESS) .Results At the end of the 4th week obvious effective and effective rate were respectively 77 .4% and 87 .1% in combination group and 42 .5% and 85 .0% in control group ,the former was significantly higher than the latter (χ2 =13 .02 ,5 .01 ;P<0 .05 or 0 .01) .Adverse reactions of both groups were mild and mainly nausea ,diaphore‐sis ,headache and so on .Conclusion Venlafaxine combined with buspirone has a synergism and an evident effect ,takes effect more rapidly ,and doesn’t increase adverse reactions compared with single venlafaxine in the treatment of treatment‐resistant depression .