临床心身疾病杂志
臨床心身疾病雜誌
림상심신질병잡지
JOURNAL OF CLINICAL PSYCHOSOMATIC DISEASES
2015年
1期
27-28,31
,共3页
抑郁症%躯体疼痛%躯体症状%度洛西汀%氟西汀%汉密顿抑郁量表%医学结局研究用疼痛量表
抑鬱癥%軀體疼痛%軀體癥狀%度洛西汀%氟西汀%漢密頓抑鬱量錶%醫學結跼研究用疼痛量錶
억욱증%구체동통%구체증상%도락서정%불서정%한밀돈억욱량표%의학결국연구용동통량표
Depression%body pain%physical symptoms%duloxetine%fluoxetine%HAMD%MOSPM
目的：探讨度洛西汀与氟西汀治疗抑郁症伴疼痛症状患者的疗效和安全性。方法将100例抑郁症伴疼痛症状患者随机分为两组，观察组口服度洛西汀治疗，对照组口服氟西汀治疗，观察8周。于治疗前后采用汉密顿抑郁量表、医学结局研究用疼痛量表评定临床疗效，副反应量表评定不良反应。结果治疗后两组各量表评分均较治疗前显著下降（P＜0．01），治疗4周末起观察组医学结局研究用疼痛量表评分显著低于对照组（ P＜0．05或0．01），治疗8周末观察组痊愈率为52．4％、总有效率为85．7％，对照组分别为48．9％、80．0％，两组比较差异无显著性（χ2＝0．11、0．50，P＞0．05）。两组不良反应较轻微，主要表现为失眠和胃肠道反应。结论度洛西汀与氟西汀均能改善抑郁症伴疼痛症状患者的抑郁、疼痛等症状，总体疗效相当，安全性高，但度洛西汀改善疼痛症状效果更显著。
目的：探討度洛西汀與氟西汀治療抑鬱癥伴疼痛癥狀患者的療效和安全性。方法將100例抑鬱癥伴疼痛癥狀患者隨機分為兩組，觀察組口服度洛西汀治療，對照組口服氟西汀治療，觀察8週。于治療前後採用漢密頓抑鬱量錶、醫學結跼研究用疼痛量錶評定臨床療效，副反應量錶評定不良反應。結果治療後兩組各量錶評分均較治療前顯著下降（P＜0．01），治療4週末起觀察組醫學結跼研究用疼痛量錶評分顯著低于對照組（ P＜0．05或0．01），治療8週末觀察組痊愈率為52．4％、總有效率為85．7％，對照組分彆為48．9％、80．0％，兩組比較差異無顯著性（χ2＝0．11、0．50，P＞0．05）。兩組不良反應較輕微，主要錶現為失眠和胃腸道反應。結論度洛西汀與氟西汀均能改善抑鬱癥伴疼痛癥狀患者的抑鬱、疼痛等癥狀，總體療效相噹，安全性高，但度洛西汀改善疼痛癥狀效果更顯著。
목적：탐토도락서정여불서정치료억욱증반동통증상환자적료효화안전성。방법장100례억욱증반동통증상환자수궤분위량조，관찰조구복도락서정치료，대조조구복불서정치료，관찰8주。우치료전후채용한밀돈억욱량표、의학결국연구용동통량표평정림상료효，부반응량표평정불량반응。결과치료후량조각량표평분균교치료전현저하강（P＜0．01），치료4주말기관찰조의학결국연구용동통량표평분현저저우대조조（ P＜0．05혹0．01），치료8주말관찰조전유솔위52．4％、총유효솔위85．7％，대조조분별위48．9％、80．0％，량조비교차이무현저성（χ2＝0．11、0．50，P＞0．05）。량조불량반응교경미，주요표현위실면화위장도반응。결론도락서정여불서정균능개선억욱증반동통증상환자적억욱、동통등증상，총체료효상당，안전성고，단도락서정개선동통증상효과경현저。
Objective To compare the efficacy and safety of duloxetine vs fluoxetine in the treatment of de‐pression patient with pain .Methods One hundred depression patients with pain were randomly assigned to two groups ,observation group took orally duloxetine and control group did fluoxetine for 8 weeks .Effi‐cacies were assessed with the Hamilton Depression Scale (HAMD) and Medical Outcomes Study Pain Measurement (MOSPM ) before and after treatment and adverse reactions with the Treatment Emergent Symptom Scale (TESS) .Results After treatment each scale scores of both groups lowered more signifi‐cantly compared with pretreatment (P<0 .01) ,since the end of the 4th week the MOSPN score was signifi‐cantly lower in observation than control group (P<0 .05 or 0 .01);at the end of the 8th week cure and total effective rate were respectively 52 .4% and 85 .7% in observation and 48 .9% and 80 .0% in control group , which showed no significant group differences (χ2 = 0 .11 ,0 .50 ;P> 0 .05) .Adverse reactions of both groups were mild and mainly insomnia and gastrointestinal reactions .Conclusion Both duloxetine and flu‐oxetine could improve depressive and painful symptoms of depression patients with pain ,their total effica‐cies are equivalent ,both have higher safety ,but duloxetine has an advantage in improving painful symp‐toms over fluoxetine .
