CAJ | 학술논문

目的：探讨艾灸肾俞穴对肾虚大鼠海马齿状回区组织形态及细胞超微结构的影响。方法将16只月龄10个月、连续配种6个月、经鉴定生殖功能下降的远交群大鼠随机分为模型组和研究组，8只月龄2个月的大鼠作为对照组。研究组给予艾灸肾俞穴治疗，模型组和对照组不予治疗。30 d后处死取材，光镜下观察海马齿状回区组织形态变化，透射电镜下观察大鼠海马齿状回区细胞超微结构变化。结果对照组大鼠海马齿状回区组织形态及细胞超微结构基本正常，模型组大鼠海马齿状回区存在组织形态及细胞超微结构病变，研究组大鼠海马齿状回区组织形态及细胞超微结构病变明显减轻。结论长期房室不节可引起大鼠海马齿状回区组织形态及细胞超微结构病变，艾灸肾俞穴有改善肾虚大鼠海马齿状回区组织形态及细胞超微结构病理改变的作用。
목적：탐토애구신유혈대신허대서해마치상회구조직형태급세포초미결구적영향。방법장16지월령10개월、련속배충6개월、경감정생식공능하강적원교군대서수궤분위모형조화연구조，8지월령2개월적대서작위대조조。연구조급여애구신유혈치료，모형조화대조조불여치료。30 d후처사취재，광경하관찰해마치상회구조직형태변화，투사전경하관찰대서해마치상회구세포초미결구변화。결과대조조대서해마치상회구조직형태급세포초미결구기본정상，모형조대서해마치상회구존재조직형태급세포초미결구병변，연구조대서해마치상회구조직형태급세포초미결구병변명현감경。결론장기방실불절가인기대서해마치상회구조직형태급세포초미결구병변，애구신유혈유개선신허대서해마치상회구조직형태급세포초미결구병리개변적작용。
Objective To observe the effects of moxibustion at acupoints Shenshu (BL23) on tissue mor‐phology and cell ultra‐structure in hippocampal dentate gyrus of sexual intemperance rats .Methods SD rats with the low reproductive capacity caused by long‐term mating for 6 months were randomly divided in‐to the kidney deficiency model group and moxibustion group .SD rats aged 2 months were the normal con‐trol group .Moxibustion group was treated by moxibustion at acupoints Shenshu (BL23) .The rats were sacrificed 2 weeks later .After the treatment of 30 days ,tissue morphology and cell ultra‐structure of hipp‐ocampal dentate gyrus was observed under light microscope and transmission electron microscopy (TEM ) . Results Compared with the model group ,tissue morphology and cell ultra‐structure of hippocampal den‐tate gyrus in moxibustion group was effectively improved .Conclusion Long‐term sexual intemperance could cause pathological changes of tissue morphology and cell ultra‐structure of hippocampal dentate gyrus of rats ,moxibustion at acupoints Shenshu could significantly alleviate tissue morphology and the cell ultra‐structure lesions of hippocampal dentate gyrus .