CAJ | 학술논문

休克是临床上常见的一种危重病，但其发生机制尚未明确，循环系统功能紊乱，尤其是微循环功能障碍是其病理生理学过程中的重要特征，并直接影响患者的治疗和复苏效果。血管内皮细胞（vascular endothelial cells， VECs）和平滑肌细胞（vasvular smooth muscle cells，VSMCs）是血管壁上的两种主要细胞，这两者间存在着的大量的缝隙连接（gap junction，GJ），GJ 是一种相邻细胞间的直接信号通道，在维持血管的正常生理功能中起着十分重要的作用。该文对 GJ 的结构、分布和功能进行阐述，并对其在休克中的作用，尤其是对休克血管功能影响方面的研究进展作一综述。
휴극시림상상상견적일충위중병，단기발생궤제상미명학，순배계통공능문란，우기시미순배공능장애시기병리생이학과정중적중요특정，병직접영향환자적치료화복소효과。혈관내피세포（vascular endothelial cells， VECs）화평활기세포（vasvular smooth muscle cells，VSMCs）시혈관벽상적량충주요세포，저량자간존재착적대량적봉극련접（gap junction，GJ），GJ 시일충상린세포간적직접신호통도，재유지혈관적정상생리공능중기착십분중요적작용。해문대 GJ 적결구、분포화공능진행천술，병대기재휴극중적작용，우기시대휴극혈관공능영향방면적연구진전작일종술。
Shock is a common serious disease,but its pathogenesis is still unclear.Shock is characterized by circulatory dysfunction,especially microcirculatory failure,which directly influ-ences the efficacy of treatment and resuscitation.There are many gap junctions,a kind of direct-signal channel between adjacent cells,between vascular endothelial cells and vascular smooth muscle cells,the two most important cells in vascular wall.Gap junctions play important roles in the maintenance of normal vascular function.This article reviews the structure,distribution and function of gap junctions and their roles in shock,especially in vascular function.