临床心身疾病杂志
臨床心身疾病雜誌
림상심신질병잡지
JOURNAL OF CLINICAL PSYCHOSOMATIC DISEASES
2015年
1期
134-135
,共2页
精神分裂症%喹硫平%舒必利%阴性症状%临床疗效%不良反应%副反应量表
精神分裂癥%喹硫平%舒必利%陰性癥狀%臨床療效%不良反應%副反應量錶
정신분렬증%규류평%서필리%음성증상%림상료효%불량반응%부반응량표
Schizophrenia%quetiapine%sulpiride%negative symptom%efficacy%adverse reaction%TESS
目的：探讨喹硫平与舒必利治疗以阴性症状为主的精神分裂症患者的临床疗效及安全性。方法将106例以阴性症状为主的精神分裂症患者随机分为两组，分别口服喹硫平、舒必利治疗，比较两组的临床疗效及不良反应。结果喹硫平组总有效率为88．7％，舒必利组为62．3％，喹硫平组显著高于舒必利组（ P＜0．01）。喹硫平组副反应量表的行为、神经系统、植物神经系统不良反应评分均显著低于舒必利组（P＜0．01）。结论喹硫平治疗以阴性症状为主的精神分裂症临床疗效显著优于舒必利，能有效改善患者的阴性症状，安全性高，值得在临床推广应用。
目的：探討喹硫平與舒必利治療以陰性癥狀為主的精神分裂癥患者的臨床療效及安全性。方法將106例以陰性癥狀為主的精神分裂癥患者隨機分為兩組，分彆口服喹硫平、舒必利治療，比較兩組的臨床療效及不良反應。結果喹硫平組總有效率為88．7％，舒必利組為62．3％，喹硫平組顯著高于舒必利組（ P＜0．01）。喹硫平組副反應量錶的行為、神經繫統、植物神經繫統不良反應評分均顯著低于舒必利組（P＜0．01）。結論喹硫平治療以陰性癥狀為主的精神分裂癥臨床療效顯著優于舒必利，能有效改善患者的陰性癥狀，安全性高，值得在臨床推廣應用。
목적：탐토규류평여서필리치료이음성증상위주적정신분렬증환자적림상료효급안전성。방법장106례이음성증상위주적정신분렬증환자수궤분위량조，분별구복규류평、서필리치료，비교량조적림상료효급불량반응。결과규류평조총유효솔위88．7％，서필리조위62．3％，규류평조현저고우서필리조（ P＜0．01）。규류평조부반응량표적행위、신경계통、식물신경계통불량반응평분균현저저우서필리조（P＜0．01）。결론규류평치료이음성증상위주적정신분렬증림상료효현저우우서필리，능유효개선환자적음성증상，안전성고，치득재림상추엄응용。
Objective To explore the efficacy and safety of quetiapine and sulpiride in schizophrenia charac‐terized by negative symptoms .Methods A total of 106 schizophrenics characterized by negative symptoms were randomly assigned to two groups taking orally quetiapine or sulpiride .Efficacy and adverse reactions were compared between two groups .Results The total effective rate was significantly higher in quetiapine than sulpiride group (88 .7% vs 62 .3% , P<0 .01) .Scores no behaviors ,nervous system and vegetative nervous system adverse reactions were significantly lower in quetiapine than sulpiride group (P<0 .01) . Conclusion Quetiapine has a more evident effect than sulpiride does in schizophrenia characterized by neg‐ative symptoms ,could effectively improve patients’ negative symptoms ,and has higher safety .
