药学研究
藥學研究
약학연구
JOURNAL OF PHARMACEUTICAL RESEARCH
2015年
1期
59-61
,共3页
药物性肝损害%中药%抗微生物药
藥物性肝損害%中藥%抗微生物藥
약물성간손해%중약%항미생물약
Drug-induced liver injury%Chinese herbs%Antimicrobial
目的：分析引起药物性肝损害的药物种类，探讨其临床特征及预后。方法回顾性分析2000~2013年CNKI载录的180例药物性肝损害的相关临床病历资料文献，对文献中患者的年龄、性别、用药情况、临床分型和预后等数据进行统计分析。结果药物性肝损害共涉及11类药物108种，最常见的药物为中药、抗微生物药。其中肝细胞损伤型78例（43.33%），胆汁淤积型49例（27.22%），混合型37例（20.56%）。结论药物性肝损害的致病药物种类繁多，用药期间定期检查肝功能，及时停用损肝药物，坚持合理用药。
目的：分析引起藥物性肝損害的藥物種類，探討其臨床特徵及預後。方法迴顧性分析2000~2013年CNKI載錄的180例藥物性肝損害的相關臨床病歷資料文獻，對文獻中患者的年齡、性彆、用藥情況、臨床分型和預後等數據進行統計分析。結果藥物性肝損害共涉及11類藥物108種，最常見的藥物為中藥、抗微生物藥。其中肝細胞損傷型78例（43.33%），膽汁淤積型49例（27.22%），混閤型37例（20.56%）。結論藥物性肝損害的緻病藥物種類繁多，用藥期間定期檢查肝功能，及時停用損肝藥物，堅持閤理用藥。
목적：분석인기약물성간손해적약물충류，탐토기림상특정급예후。방법회고성분석2000~2013년CNKI재록적180례약물성간손해적상관림상병력자료문헌，대문헌중환자적년령、성별、용약정황、림상분형화예후등수거진행통계분석。결과약물성간손해공섭급11류약물108충，최상견적약물위중약、항미생물약。기중간세포손상형78례（43.33%），담즙어적형49례（27.22%），혼합형37례（20.56%）。결론약물성간손해적치병약물충류번다，용약기간정기검사간공능，급시정용손간약물，견지합리용약。
Pbjective To analyze the clinical characteristics and causative agents of drug—induced liver injury( DIL-I). Methods 180 cases of drug—induced liver injury in CNKI between 2000 and 2013 were retrospectively analyzed,and the data of age,gender,medication,clinical manifestation and prognosis were analyzed. ResuIts A total of 11 categories of drugs caused by 108 kinds of drugs is involved in 180 cases. The common drugs including DILI were Chinese herbs and an-timicrobial. The clinical types of DILI in these cases included hepatocellular injury type( 43. 33%),cholestasis type (27. 22%)and mixed type(20. 56%). ConcIusion The types of drug—induced liver injury drugs were diverse. During the course of medication,regularly checking liver function and discontinuation of the suspected drugs was the principal man-agement for the disease.
