药品评价
藥品評價
약품평개
DRUG REEVALUATION
2014年
22期
21-23,29
,共4页
王丽莉%李叶丰%王娴%魏媛怡%潘莉%王春霞
王麗莉%李葉豐%王嫻%魏媛怡%潘莉%王春霞
왕려리%리협봉%왕한%위원이%반리%왕춘하
高效液相色谱法%莫西沙星注射液%苦参碱注射液%配伍稳定性
高效液相色譜法%莫西沙星註射液%苦參堿註射液%配伍穩定性
고효액상색보법%막서사성주사액%고삼감주사액%배오은정성
HPLC%Moxifloxacin Hydrochloride Injection%Matrine Injection%stability
目的：考察莫西沙星注射液和苦参碱注射液的配伍稳定性，为临床用药安全提供实验依据。方法：模拟临床常用浓度和配制方法，观察莫西沙星注射液和苦参碱注射液配伍后，在8h内配伍液的外观、pH值，并采用高效液相色谱法(HPLC)测定其含量变化。结果：配伍溶液的外观和p H值无明显变化，苦参碱和盐酸莫西沙星8h内其相对百分含量无明显变化。结论：在25℃和37℃下，苦参碱和盐酸莫西沙星配伍后8h内是稳定的。
目的：攷察莫西沙星註射液和苦參堿註射液的配伍穩定性，為臨床用藥安全提供實驗依據。方法：模擬臨床常用濃度和配製方法，觀察莫西沙星註射液和苦參堿註射液配伍後，在8h內配伍液的外觀、pH值，併採用高效液相色譜法(HPLC)測定其含量變化。結果：配伍溶液的外觀和p H值無明顯變化，苦參堿和鹽痠莫西沙星8h內其相對百分含量無明顯變化。結論：在25℃和37℃下，苦參堿和鹽痠莫西沙星配伍後8h內是穩定的。
목적：고찰막서사성주사액화고삼감주사액적배오은정성，위림상용약안전제공실험의거。방법：모의림상상용농도화배제방법，관찰막서사성주사액화고삼감주사액배오후，재8h내배오액적외관、pH치，병채용고효액상색보법(HPLC)측정기함량변화。결과：배오용액적외관화p H치무명현변화，고삼감화염산막서사성8h내기상대백분함량무명현변화。결론：재25℃화37℃하，고삼감화염산막서사성배오후8h내시은정적。
Objective: To investigate the compatibility and stability of moxifloxacin hydrochloride injection and matrine injection, to provide an experimental basis for clinical drug safety. Methods:According to the common concentration and preparation methods used in clinic, the appearance and PH value were observed; the concentrations were determined by HPLC after combination of morxifloxacin hydrochloride injection and matrine injection within 8 hours. Results: The appearance and PH of compatibility solution had no significant changes and its relative contents did not change markedly within 8 hours. Conclusion:The compatibility of moxifloxacin hydrochloride injection and matrine injection within 8h is stable at 25℃and 37℃.
