现代诊断与治疗
現代診斷與治療
현대진단여치료
MODERN DIAGNOSIS AND TREATMENT
2014年
20期
4563-4564
,共2页
甲状腺疾病%自生免疫病%糖尿病
甲狀腺疾病%自生免疫病%糖尿病
갑상선질병%자생면역병%당뇨병
Thyroid disease%Self￣immune disease%Diabetes
目的：对成人隐匿性自身免疫糖尿病（LADA）与甲状腺自身免疫之间的关系进行探讨。方法选取在我院就诊的300例糖尿病患者，其中包括94例LADA患者，100例1型糖尿病(T1DM）患者，106例2型糖尿病（T2DM）患者，并与100例健康人群相对照，对健康人群与患病人群均进行甲状腺球蛋白抗体（TG￣Ab）及甲状腺过氧化物酶抗体检测（TPO￣Ab）检测，糖尿病患者还需进行谷氨酸脱羧酶检测（GAD￣Ab），比较检查结果的差异性。结果(1)LADA组的阳性检出率均较正常对照组高(P＜0.05)，同时与T2DM组相比,LADA组与T1DM组的TPO-Ab检出率更高(P＜0.05),而LADA组与T1DM组的检出率之间无显著性差异(P＞0.05)。(2)对于LADA患者，甲状腺抗体检测阳性的患者其甲状腺功能异常发生率高于抗体检测阴性者，两组之间无显著性差异(P＞0.05)。结论通过甲状腺抗体检测，发现LADA患者的甲状腺功能异常的发生风险较大，其十分容易合并自身的甲状腺免疫紊乱。
目的：對成人隱匿性自身免疫糖尿病（LADA）與甲狀腺自身免疫之間的關繫進行探討。方法選取在我院就診的300例糖尿病患者，其中包括94例LADA患者，100例1型糖尿病(T1DM）患者，106例2型糖尿病（T2DM）患者，併與100例健康人群相對照，對健康人群與患病人群均進行甲狀腺毬蛋白抗體（TG￣Ab）及甲狀腺過氧化物酶抗體檢測（TPO￣Ab）檢測，糖尿病患者還需進行穀氨痠脫羧酶檢測（GAD￣Ab），比較檢查結果的差異性。結果(1)LADA組的暘性檢齣率均較正常對照組高(P＜0.05)，同時與T2DM組相比,LADA組與T1DM組的TPO-Ab檢齣率更高(P＜0.05),而LADA組與T1DM組的檢齣率之間無顯著性差異(P＞0.05)。(2)對于LADA患者，甲狀腺抗體檢測暘性的患者其甲狀腺功能異常髮生率高于抗體檢測陰性者，兩組之間無顯著性差異(P＞0.05)。結論通過甲狀腺抗體檢測，髮現LADA患者的甲狀腺功能異常的髮生風險較大，其十分容易閤併自身的甲狀腺免疫紊亂。
목적：대성인은닉성자신면역당뇨병（LADA）여갑상선자신면역지간적관계진행탐토。방법선취재아원취진적300례당뇨병환자，기중포괄94례LADA환자，100례1형당뇨병(T1DM）환자，106례2형당뇨병（T2DM）환자，병여100례건강인군상대조，대건강인군여환병인군균진행갑상선구단백항체（TG￣Ab）급갑상선과양화물매항체검측（TPO￣Ab）검측，당뇨병환자환수진행곡안산탈최매검측（GAD￣Ab），비교검사결과적차이성。결과(1)LADA조적양성검출솔균교정상대조조고(P＜0.05)，동시여T2DM조상비,LADA조여T1DM조적TPO-Ab검출솔경고(P＜0.05),이LADA조여T1DM조적검출솔지간무현저성차이(P＞0.05)。(2)대우LADA환자，갑상선항체검측양성적환자기갑상선공능이상발생솔고우항체검측음성자，량조지간무현저성차이(P＞0.05)。결론통과갑상선항체검측，발현LADA환자적갑상선공능이상적발생풍험교대，기십분용역합병자신적갑상선면역문란。
Objective To discusses the relationship between adult-onset latent autoimmune dia-betes (LADA)and thyroid autoimmunity. Methods 300 cases of diabetic patients including 94 cases of LADA patients, 100 T1DM patients, 106 T2DM patients, were compared with 100 cases of healthy people. They are detected thyroglobulin antibody (TG￣Ab) and thyroid peroxidase anti-body detection (TPO￣Ab), at the same time patients with diabetes accepted glutamic acid decar-boxylase (GAD￣Ab) detection, compared the differences of test. Results (1)The positive detection rate of LADA group was higher than normal control group (P<0.05), compared with T2DM group, the T1DM group of TPO￣Ab detection rate was higher (P<0.05), while, the detection rate in the T1DM group and LADA group was no significant difference (P>0.05). (2)For LADA patients, ab-normal thyroid function rate in patients with thyroid antibody detection positive rate was higher than the negative antibody detection, there was no significant difference between two groups (P>0.05).Conclusion By thyroid antibody detection, the risk of thyroid dysfunction in patients is big-ger, it's easy to merge their own immune thyroid disorders.
