CAJ | 학술논문

目的：探讨整合素连接激酶(Integrin-linked kinase,ILK)和基质金属蛋白酶-9(matrix metalloproteinases-9,MMP-9)在胃癌组织中的表达、临床意义及两者之间的关系。方法应用免疫组织化学SP方法检测ILK和MMP-9在80例胃癌(胃癌组)、30例正常胃黏膜标本(对照组)中的表达,并统计分析其与临床病理参数之间的关系。结果80例胃癌标本中ILK和MMP-9的阳性表达率分别为55.0%(44/80)、66.3%(53/80),30例对照组中ILK和MMP-9的阳性表达率分别为6.7%(2/30)、10.0%(3/30),胃癌组织中ILK和MMP-9的阳性表达率明显高于对照组(P<0.05)。 ILK和MMP-9的表达与癌组织分化程度、浸润深度、淋巴结转移及大网膜转移有显著相关性(P<0.05),而与患者的年龄、性别及肿瘤大小无相关性(P>0.05)。 ILK表达与MMP-9表达有显著相关性(r=0.553, P<0.01)。结论 ILK和MMP-9在胃癌组织中均呈高表达且二者表达有协同作用,胃癌细胞可能通过ILK和MMP-9促进浸润、转移,联合检测两者表达有助于胃癌浸润、转移的判断。
목적：탐토정합소련접격매(Integrin-linked kinase,ILK)화기질금속단백매-9(matrix metalloproteinases-9,MMP-9)재위암조직중적표체、림상의의급량자지간적관계。방법응용면역조직화학SP방법검측ILK화MMP-9재80례위암(위암조)、30례정상위점막표본(대조조)중적표체,병통계분석기여림상병리삼수지간적관계。결과80례위암표본중ILK화MMP-9적양성표체솔분별위55.0%(44/80)、66.3%(53/80),30례대조조중ILK화MMP-9적양성표체솔분별위6.7%(2/30)、10.0%(3/30),위암조직중ILK화MMP-9적양성표체솔명현고우대조조(P<0.05)。 ILK화MMP-9적표체여암조직분화정도、침윤심도、림파결전이급대망막전이유현저상관성(P<0.05),이여환자적년령、성별급종류대소무상관성(P>0.05)。 ILK표체여MMP-9표체유현저상관성(r=0.553, P<0.01)。결론 ILK화MMP-9재위암조직중균정고표체차이자표체유협동작용,위암세포가능통과ILK화MMP-9촉진침윤、전이,연합검측량자표체유조우위암침윤、전이적판단。
Objective To investigate the expression and clinical significance of ILK and MMP-9 in gastric cancer in-vasion and metastasi. Methods A total of 80 cases of gastric cancer ( gastric cancer group) and 30 cases of normal gas-tric tissue ( normal control group) were enrolled in this study. Immunohistochemical staining was performed to detect the expression of ILK and MMP-9 in gastric cancer. Statistical analysis technique was used to investigate the relationship be-tween ILK and MMP-9 expressions and the clinicopathological factors. Results The positive rates of ILK and MMP-9 in gastric cancer tissue were 55. 0% (44/80) and 66. 3% (53/80). In the normal control group, the positive rates of ILK and MMP-9 were 6. 7% (2/30) and 10. 0% (3/30), respectively. The expression of ILK and MMP-9 in gastric cancer tissues were significantly higher than that in normal control group ( P<0 . 05 ) . Both ILK and MMP-9 were correlated with tumor differentiation, invasion depth, lymph node metastasis and omentum metastasis (P<0. 05). The tumor pri-mary diameter, gender and age were not associated with the expression of ILK and MMP-9 (P>0. 05). There was a re-markable relevance between ILK and MMP-9 ( r =0 . 553 , P <0 . 01 ) . Conclusion ILK and MMP-9 are highly ex-pressed in gastric cancer tissues. The expression of them is coordinated and significantly related to the invasion and me-tastasis of gastric cancer. The expression of ILK and MMP-9 can suggest the malignant degree of gastric cancer and be the important indicator of prognosis.