CAJ | 학술논문

目的：通过检测不同冠状动脉病变程度患者的血清肝脏激酶B1（LKB1）水平，探讨其在冠状动脉粥样硬化性心脏病（冠心病）的临床意义。方法30例 AMI 患者为 A 组，选择同期性别、年龄匹配的冠状动脉狭窄患者30例（B 组）及冠状动脉正常患者30名（C 组）作为对照。所有患者均行冠状动脉造影检查，于术前30 mim 抽取外周血，用 ELISA 法测定 LKB1血清浓度，并比较各组的差异。结果与 C 组[（4.32±1.68）ng／ml]比较，A 组[（3.13±1.15）ng／ml]和 B 组[（3.41±0.88）ng／ml]LKB1水平均较低（P 分别为0.001和0.006）。A 组与 B 组间 LKB1水平比较差异无统计学意义（P ＝0.369）。结论LKB1在冠心病患者明显降低，可能可以作为新的无创性检测冠心病的生物标记。
목적：통과검측불동관상동맥병변정도환자적혈청간장격매B1（LKB1）수평，탐토기재관상동맥죽양경화성심장병（관심병）적림상의의。방법30례 AMI 환자위 A 조，선택동기성별、년령필배적관상동맥협착환자30례（B 조）급관상동맥정상환자30명（C 조）작위대조。소유환자균행관상동맥조영검사，우술전30 mim 추취외주혈，용 ELISA 법측정 LKB1혈청농도，병비교각조적차이。결과여 C 조[（4.32±1.68）ng／ml]비교，A 조[（3.13±1.15）ng／ml]화 B 조[（3.41±0.88）ng／ml]LKB1수평균교저（P 분별위0.001화0.006）。A 조여 B 조간 LKB1수평비교차이무통계학의의（P ＝0.369）。결론LKB1재관심병환자명현강저，가능가이작위신적무창성검측관심병적생물표기。
Objective To compare the differences of serum liver kinase B1 (LKB1)in patients with varying degree of coronary artery disease and explore its clinical significance for coronary heart disease.Meth-ods Thirty patients with acute myocardial infarction (AMI)were assigned to group A.Thirty age-and sex-matched subjects with coronary artery stenosis were recruited in group B and 30 subjects with normal coronary artery were recruited in group C.All participants underwent coronary angiography.At preoperative 30 min,pe-riphery blood sample was collected.The serum LKB1 was determined using ELISA and statistically compared a-mong three groups.Results The serum LKB1 in group A was (3.13 ±1.15)ng/ml and (3.41 ±0.88)ng/ml in group B,significantly lower compared with that in group C (P =0.001 and P =0.006).The serum LKB1 did not significantly differ between groups A and B (P =0.369).Conclusions The level of LKB1 is significantly decreased in patients with coronary artery disease,which may serve as a novel non-invasive bio-marker of diagnosing coronary artery disease.