CAJ | 학술논문

目的：探讨喹硫平对精神分裂症患者甲状腺激素及血糖、血脂水平的影响。方法：对30例精神分裂症患者口服喹硫平治疗，观察12周。治疗前后分别测定血清三碘甲状腺原氨酸（ T3）、甲状腺素（ T4）、游离三碘甲状腺原氨酸（ FT3）、游离甲状腺素（FT4）、促甲状腺素（TSH）、空腹血糖（GLU）、胆固醇（TC）和甘油三酯（TG）水平的变化，并对各因素水平变化进行相关性分析。结果：与治疗前比较，血清T3和FT3水平分别有显著降低（ P＜0.01、P＜0.05）。 T4、FT4水平显著降低（ P＜0.05）。TSH变化无统计学差异。 TC、TG和 GLU水平显著升高（ P＜0.05、P＜0.01、P＜0.05）；T3变化与TG变化呈显著负相关（ P＜0.05）。 FT3变化与TC变化呈正相关（P＜0.05），其他因素间均无相关性。结论：喹硫平能降低精神分裂症患者甲状腺激素水平，升高血糖、血脂水平，且甲状腺激素水平与血脂代谢有一定的相关性。
목적：탐토규류평대정신분렬증환자갑상선격소급혈당、혈지수평적영향。방법：대30례정신분렬증환자구복규류평치료，관찰12주。치료전후분별측정혈청삼전갑상선원안산（ T3）、갑상선소（ T4）、유리삼전갑상선원안산（ FT3）、유리갑상선소（FT4）、촉갑상선소（TSH）、공복혈당（GLU）、담고순（TC）화감유삼지（TG）수평적변화，병대각인소수평변화진행상관성분석。결과：여치료전비교，혈청T3화FT3수평분별유현저강저（ P＜0.01、P＜0.05）。 T4、FT4수평현저강저（ P＜0.05）。TSH변화무통계학차이。 TC、TG화 GLU수평현저승고（ P＜0.05、P＜0.01、P＜0.05）；T3변화여TG변화정현저부상관（ P＜0.05）。 FT3변화여TC변화정정상관（P＜0.05），기타인소간균무상관성。결론：규류평능강저정신분렬증환자갑상선격소수평，승고혈당、혈지수평，차갑상선격소수평여혈지대사유일정적상관성。
Objective:To explore the influences of quetiapine on thyroxine, blood glucose, lipid levels of schizophrenia patients.Methods:30 schizophrenia patients took orally quetiapine for 12 weeks.Changes of thyroxine, blood glucose,lipid levels were detected before and after treatment, and analyze correlations of between factor changes.Results:T3 and FT3 were significantly decreased than be-fore treatment (P<0.01, P<0.05).T4 and FT4 was significantly decreased (P<0.05).There was no significant difference in serum TSH compared with pre-treatment.TC, TG and GLU were significantly increased (P<0.05, P<0.01, P<0.05).Changes between T3 and TG were negatively correlated (P<0.05).Changes between FT3 and TC were positively correlated(P<0.05).Other facters had no correlation.Conclusion:Quetiapine could reduce thyroid, and elevated blood glucose,lipid levels of schizophrenia patients.Thyroid hor-mone levels had a certain correlation with blood lipid metabolism.