CAJ | 학술논문

目的：观察银杏叶注射液对于肺癌患者血液高凝状态的疗效及其安全性。方法选取2010年10月至2014年10月河北大学附属医院收治109例晚期肺癌患者作为研究对象，随机分成治疗组（50例）和对照组（59例）。对照组仅行全身化疗，治疗组予以全身化疗联合应用银杏叶注射液，7 d 为1个疗程，治疗2个疗程后对比2组疗效及Fib（血浆纤维蛋白原）、D-D（D-二聚体）水平。结果治疗组的改善率为81.36%（48/59），对照组的为26%（13/50）；治疗组无效率为8.47%（5/59），对照组的为32%（16/50）；治疗组稳定率为10.17%（6/59），对照组的为42%（21/50）（均P<0.05）。治疗组治疗前和对照组治疗前Fib、D-D水平差异无统计学意义（P>0.05），而治疗后的Fib、D-D均显著低于对照组治疗后的Fib 、D-D，差异有统计学意义（P<0.05）。治疗组与对照组Fib和D-D水平治疗前后差值比较（P<0.05），治疗组疗效优于对照组。治疗组未出现明显不良反应。结论银杏叶注射液能改善肺癌患者血液高凝状态，疗效及安全性均较好。
목적：관찰은행협주사액대우폐암환자혈액고응상태적료효급기안전성。방법선취2010년10월지2014년10월하북대학부속의원수치109례만기폐암환자작위연구대상，수궤분성치료조（50례）화대조조（59례）。대조조부행전신화료，치료조여이전신화료연합응용은행협주사액，7 d 위1개료정，치료2개료정후대비2조료효급Fib（혈장섬유단백원）、D-D（D-이취체）수평。결과치료조적개선솔위81.36%（48/59），대조조적위26%（13/50）；치료조무효솔위8.47%（5/59），대조조적위32%（16/50）；치료조은정솔위10.17%（6/59），대조조적위42%（21/50）（균P<0.05）。치료조치료전화대조조치료전Fib、D-D수평차이무통계학의의（P>0.05），이치료후적Fib、D-D균현저저우대조조치료후적Fib 、D-D，차이유통계학의의（P<0.05）。치료조여대조조Fib화D-D수평치료전후차치비교（P<0.05），치료조료효우우대조조。치료조미출현명현불량반응。결론은행협주사액능개선폐암환자혈액고응상태，료효급안전성균교호。
Objective To observe the efficacy and safety of Ginkgo biloba injection in treating blood hypercoagulable state of patients with advanced lung cancer.Methods 109 cases with advanced lung cancer in the Afifliated Hospital of Hebei University were divided into experimental group (50 cases) and control group (59 cases) between 2010.10 to 2014.10. The patients of the control group were treated only with systemic chemotherapy, those of the experimental group were also treated with chemotherapy combined with Ginkgo biloba injection. Fib, D-D levels and curative effects were compared after 2 courses of treatment, which one period of treatment was 7 days.Results The improvement rate of experimental group was 81.36% (48/59), and 26% (13/50) in the control group. Inefifciency in the experimental group and control group was 8.47% (5/59)and 32% (16/50), and the stability factor was 10.17% (6/59) and 42% (21/50) ( bothP<0.05). Comparing two groups, the Fib and D-D levels did not have any significant difference before treatment (P>0.05). However, the two levels of the experimental group were lower than those of the control group after treatment, and the difference was significant (P<0.05). The difference about the Fib and D-D levels before and after treatment between the experimental group and the control group was signiifcant (P<0.05), showing that the curative effect of the experimental group was better than that of the control group.Experimental group did not appear obvious adverse reactions.Conclusion Ginkgo biloba injection can improve blood hypercoagulable state of patients with lung cancer, which is effective and safety.