CAJ | 학술논문

目的：观察舒芬太尼联合氟比洛芬酯在下肢骨折患者术后镇痛中的应用效果及不良反应。方法择期行下肢骨折切开复位内固定术患者60例，按照随机数字表法分为2组，每组30例。2组患者术后均使用一次性均速镇痛泵，观察组镇痛泵内药物配方应用舒芬太尼联合氟比洛芬酯，对照组镇痛泵内药物配方应用舒芬太尼，其他药物相同。记录术后2 h、4 h、8 h、12 h、24 h疼痛视觉模拟评分及不良反应情况。结果2组患者术后各时点疼痛视觉模拟评分组间比较差异无统计学意义（P>0.05）。对照组患者恶心、呕吐、呼吸抑制、心动过缓、镇静过度等不良反应发生率明显高于观察组（P<0.05或0.01）。结论舒芬太尼联合氟比洛芬酯应用于下肢骨折患者术后镇痛效果理想，安全性高。
목적：관찰서분태니연합불비락분지재하지골절환자술후진통중적응용효과급불량반응。방법택기행하지골절절개복위내고정술환자60례，안조수궤수자표법분위2조，매조30례。2조환자술후균사용일차성균속진통빙，관찰조진통빙내약물배방응용서분태니연합불비락분지，대조조진통빙내약물배방응용서분태니，기타약물상동。기록술후2 h、4 h、8 h、12 h、24 h동통시각모의평분급불량반응정황。결과2조환자술후각시점동통시각모의평분조간비교차이무통계학의의（P>0.05）。대조조환자악심、구토、호흡억제、심동과완、진정과도등불량반응발생솔명현고우관찰조（P<0.05혹0.01）。결론서분태니연합불비락분지응용우하지골절환자술후진통효과이상，안전성고。
Objective To investigate the application results and adverse reactions of sufentanil combined with lfurbiprofen in relieving postoperative analgesia in patients with lower limb fractures.Methods 60 patients with lower extremity fractures underwent open reduction and internal ifxation (ORIF) were selected in our hospital, according to a random number table they were divided into two groups, 30 cases in each group. The patients of the two groups were using disposable constant speed analgesia pump after operation, the observation group applying analgesia pump recipe sufentanil combined with flurbiprofen, the control group using sufentanil. Record pain visual analog scale and adverse reactions after operation for 2 h, 4 h, 8 h, 12 h, 24 h.Results There was not statistically signiifcance considering analgesic effects in the 2 groups and the difference of point pain visual analog scale groups after operation (P> 0.05). The complications such as nausea, vomiting, respiratory depression, bradycardia, sedation and other adverse reactions in the controls were signiifcantly higher than in the observation group (P <0.05 or 0.01).Conclusion Sufentanil combined with lfurbiprofen is a safe and ideal analgesia medicine used in patients with lower limb fractures.