CAJ | 학술논문

目的：研究骨髓增殖性肿瘤（MPN）患者JAK2V617F突变与脑血管事件的相关性。方法检测64例MPN患者JAK2V617F突变情况，回顾性分析64例MPN患者脑血管事件（脑梗死、短暂性脑缺血发作、脑出血、蛛网膜下腔出血）发生情况等资料，统计分析JAK2V617F突变阳性组与阴性组脑血管事件的发生率，并分析JAK2V617F突变阳性的不同病种间脑血管事件发生率。结果64例MPN患者中47例（73.4%）存在JAK2V617F突变，38例有脑血管事件（59.4%），JAK2V617F突变阳性和阴性患者中脑血管事件发生率分别为68.1%和35.3%，2组间P=0.018。JAK2V617F突变阳性的PV和ET患者脑血管事件发生率差异无统计学意义。结论JAK2V617F突变阳性较突变阴性的MPN患者脑血管事件发生的风险可能更高。
목적：연구골수증식성종류（MPN）환자JAK2V617F돌변여뇌혈관사건적상관성。방법검측64례MPN환자JAK2V617F돌변정황，회고성분석64례MPN환자뇌혈관사건（뇌경사、단잠성뇌결혈발작、뇌출혈、주망막하강출혈）발생정황등자료，통계분석JAK2V617F돌변양성조여음성조뇌혈관사건적발생솔，병분석JAK2V617F돌변양성적불동병충간뇌혈관사건발생솔。결과64례MPN환자중47례（73.4%）존재JAK2V617F돌변，38례유뇌혈관사건（59.4%），JAK2V617F돌변양성화음성환자중뇌혈관사건발생솔분별위68.1%화35.3%，2조간P=0.018。JAK2V617F돌변양성적PV화ET환자뇌혈관사건발생솔차이무통계학의의。결론JAK2V617F돌변양성교돌변음성적MPN환자뇌혈관사건발생적풍험가능경고。
Objective To investigate the relationship of JAK2V617F mutation and cerebrovascular events in patients with myeloproliferative neoplasms(MPN).Methods The JAK2V617F mutation of 64 patients with MPN was detected. We performed a retrospective study on the incidence of cerebrovascular events(cerebral infarction, transient ischemic attack, cerebral hemorrhage, subarachnoid hemorrhage) in 64 patients with MPN. Statistical analysis was applied on the incidence rate of cerebrovascular events between JAK2V617F mutation positive group and negative group and between groups of different diseases with JAK2V617F mutation.Results Of 64 patients with MPN, JAK2V617F mutation was detected in 47 cases (73.4%). There were a total of 38(59.4%) cerebrovascular events. The incidence rate of cerebrovascular events in JAK2V617F mutation positive and negative patients were 68.1% and 35.3% respectively, P=0.018. The incidence rate between PV and ET patients with JAK2V617F mutation were statistically non-signiifcant.Conclusion The risk of cerebrovascular events in MPN patients with JAK2V617F mutation may be higher.