CAJ | 학술논문

自噬（autophagy）是普遍存在于真核细胞中的一种依赖溶酶体的胞内降解系统。它是一种适应性的代谢反应，能清除细胞中损伤或衰老细胞器及生物大分子，是一种高度保守的维持自身稳态的重要调节机制。近年研究发现，自噬与肾脏缺血再灌注等急性肾损伤、药物性肾损害、遗传性肾脏病、糖尿病肾病等肾脏疾病的发病及肾脏衰老有关。因此，自噬未来可能作为治疗肾脏疾病的一个新靶点。
자서（autophagy）시보편존재우진핵세포중적일충의뢰용매체적포내강해계통。타시일충괄응성적대사반응，능청제세포중손상혹쇠로세포기급생물대분자，시일충고도보수적유지자신은태적중요조절궤제。근년연구발현，자서여신장결혈재관주등급성신손상、약물성신손해、유전성신장병、당뇨병신병등신장질병적발병급신장쇠로유관。인차，자서미래가능작위치료신장질병적일개신파점。
Autophagy generally exists in eukaryotic cells,and is an intracellular degradation system dependent on lysosomes.Autophagy is an adaptive metabolic response,can eliminate damaged or senile organelles and biological macromolecules in the cell.It is a kind of highly conservative and important regulatory mechanism to maintain steady state of cells.In recent years,studies showed that autophagy was associated with acute kidney injury, drug-induced renal damage, hereditary kidney disease, diabetic nephropathy,and renal senescence.Therefore,autophagy may be a novel therapeutic target of kidney diseases in the future.