创伤与急诊电子杂志
創傷與急診電子雜誌
창상여급진전자잡지
Journal of Trauma and Emergency (Electronic Version)
2014年
4期
12-15
,共4页
百草枯中毒%乌司他丁%自由基清除剂%肺纤维化%肝功能不全%肾功能不全
百草枯中毒%烏司他丁%自由基清除劑%肺纖維化%肝功能不全%腎功能不全
백초고중독%오사타정%자유기청제제%폐섬유화%간공능불전%신공능불전
Paraquat poisoning%Ulinastatin%Free radical scavenger%Pulmonary fibrosis%Hypohepatia%Renal inadequacy
目的：评价乌司他丁联合多种自由基清除剂（依达拉奉、维生素E、维生素C）治疗急性百草枯中毒的效果。方法采取回顾研究方法，选择福建省急救中心2009年8月至2014年7月收治的急性百草枯中毒患者153例为研究对象，分析其治疗方案的差异后将其分为观察组69例和对照组84例(对照组采用常规治疗方法，而观察组在常规治疗方法基础上加用乌司他丁及自由基清除剂)。评估治疗过程中患者肝肾功能、肺部HRCT变化等指标。结果治疗2周后观察组肝肾功等指标对比对照组均明显改善；肺部HRCT显示观察组肺部渗出及间质纤维化程度对比对照组明显减少，差异有统计学意义（P<0.05）。结论早期应用乌司他丁联合多种自由基清除剂可减轻百草枯对肝肾及肺部的损害。
目的：評價烏司他丁聯閤多種自由基清除劑（依達拉奉、維生素E、維生素C）治療急性百草枯中毒的效果。方法採取迴顧研究方法，選擇福建省急救中心2009年8月至2014年7月收治的急性百草枯中毒患者153例為研究對象，分析其治療方案的差異後將其分為觀察組69例和對照組84例(對照組採用常規治療方法，而觀察組在常規治療方法基礎上加用烏司他丁及自由基清除劑)。評估治療過程中患者肝腎功能、肺部HRCT變化等指標。結果治療2週後觀察組肝腎功等指標對比對照組均明顯改善；肺部HRCT顯示觀察組肺部滲齣及間質纖維化程度對比對照組明顯減少，差異有統計學意義（P<0.05）。結論早期應用烏司他丁聯閤多種自由基清除劑可減輕百草枯對肝腎及肺部的損害。
목적：평개오사타정연합다충자유기청제제（의체랍봉、유생소E、유생소C）치료급성백초고중독적효과。방법채취회고연구방법，선택복건성급구중심2009년8월지2014년7월수치적급성백초고중독환자153례위연구대상，분석기치료방안적차이후장기분위관찰조69례화대조조84례(대조조채용상규치료방법，이관찰조재상규치료방법기출상가용오사타정급자유기청제제)。평고치료과정중환자간신공능、폐부HRCT변화등지표。결과치료2주후관찰조간신공등지표대비대조조균명현개선；폐부HRCT현시관찰조폐부삼출급간질섬유화정도대비대조조명현감소，차이유통계학의의（P<0.05）。결론조기응용오사타정연합다충자유기청제제가감경백초고대간신급폐부적손해。
Objective To evaluate the value of ulinastatin combined with free radical scavenger in the treatment of acute paraquat poisoning.Method 153 acute paraquat poisoning patients in our hospital were selected from August 2009 to July 2014.They were divided into the control group(conventional treatment,84 cases)and the treatment group(ulinastatin combined with free radical scavenger plus conventional treatment,69 cases)according to the treatment method to find the differences between the two groups in the pulmonary fibrosis, hypohepatia and renal inadequacy.Result After two weeks of treatment, the pulmonary fibrosis,hypohepatia and renal inadequacy in the treatment group reduced significantly compared with the control group,and the differences were statistically significant(P<0.05).Conclusion Ulinastatin combined with free radical scavenger in the treatment of acute paraquat poisoning can protect organ functions and reduce the incidence of pulmonary fibrosis,hypohepatia as well as renal inadequacy.
