CAJ | 학술논문

目的：研究局部应用外源性重组人血管内皮生长因子（rhVEGF）对大鼠正畸牙牙齿移动距离和体质量的影响。方法建立SD大鼠正畸牙近中移动动物模型，将30只模型大鼠按 rh‐VEGF注射剂量不同随机分为0（对照组）、1 ng、5 ng、10 ng、15 ng和20 ng组，每组5只，将不同剂量rhVEGF每3 d注射于模型大鼠左上颌第一磨牙颊侧牙龈黏膜下，10 d后处死，测量牙齿移动距离并监测体质量的改变。结果注射 rhVEGF剂量低于5 ng 时牙齿移动距离较小，随剂量增大而增加，5 ng 时到达高峰值，与对照组比较差异有统计学意义（ P＜0．05）；随后牙齿移动距离随剂量增加而减小；其余剂量组与对照组比较差异均无统计学意义（P＞0．05）。各组大鼠处死时体质量均比实验前轻，但各组间差异无统计学意义（P＞0．05）。结论一定剂量范围内的外源性rhVEGF可加快正畸牙移动，局部短时间内应用外源性rhVEGF对正畸模型大鼠体质量无明显影响。
목적：연구국부응용외원성중조인혈관내피생장인자（rhVEGF）대대서정기아아치이동거리화체질량적영향。방법건립SD대서정기아근중이동동물모형，장30지모형대서안 rh‐VEGF주사제량불동수궤분위0（대조조）、1 ng、5 ng、10 ng、15 ng화20 ng조，매조5지，장불동제량rhVEGF매3 d주사우모형대서좌상합제일마아협측아간점막하，10 d후처사，측량아치이동거리병감측체질량적개변。결과주사 rhVEGF제량저우5 ng 시아치이동거리교소，수제량증대이증가，5 ng 시도체고봉치，여대조조비교차이유통계학의의（ P＜0．05）；수후아치이동거리수제량증가이감소；기여제량조여대조조비교차이균무통계학의의（P＞0．05）。각조대서처사시체질량균비실험전경，단각조간차이무통계학의의（P＞0．05）。결론일정제량범위내적외원성rhVEGF가가쾌정기아이동，국부단시간내응용외원성rhVEGF대정기모형대서체질량무명현영향。
Objective To observe the effect of recombinant human vascular endothelial growth factor ( rhVEGF) on orthodontic tooth movement and weight in rats .Methods Model for orthodontic tooth movement was established in 30 SD rats ,which were divided into six groups (n=5 ,each group) and injected respectively with different doses of rhVEGF(0(the control group) ,1 ,5 10 ,15 ,20ng) in‐to the palatal submucosal area adjacent to the left upper first molar once per 3 days .The animals were sacrificed on tenth day ,and the distances of tooth movement and animal weight were measured .Results The maximum tooth movement was observed in the 5ng group .The weight changes of all animal were not obviously .Conclusion Within certain limits ,exogenous rhVEGF can accelerate the orthodontic tooth movement ,and has no effect body weight in a short period of time .