功能材料
功能材料
공능재료
JOURNAL OF FUNCTIONAL MATERIALS
2015年
5期
5067-5071
,共5页
超声辅助%复乳法%多孔羟基磷灰石微球%骨组织修复%药物控释
超聲輔助%複乳法%多孔羥基燐灰石微毬%骨組織脩複%藥物控釋
초성보조%복유법%다공간기린회석미구%골조직수복%약물공석
ultra-assisted%multiple emulsion%porous HAP microspheres%bone tissue engineering%drug delivery
采用超声辅助复乳法制备多孔 H AP 微球,通过调节反应温度、时间和 pH 值条件,获得了粒径分布均匀、形貌规则,具有不规则纳米多孔结构的 H AP微球。通过XRD、IR、SEM、TEM对微球进行了表征,研究了实验条件对产物成分及形貌的影响。结果表明,适宜的合成条件为：反应温度50℃,反应时间24 h,内水相pH 值≥10,在此条件下制备的产物为球形 HAP 粒子,直径分布在50~200 nm 之间,尺寸比较均一,每个微球由大量的纳米 H AP 粒子堆积而成,微球呈现疏松多孔结构。这种多孔 H AP 微球在骨组织修复及药物控释材料方面具有应用前景。
採用超聲輔助複乳法製備多孔 H AP 微毬,通過調節反應溫度、時間和 pH 值條件,穫得瞭粒徑分佈均勻、形貌規則,具有不規則納米多孔結構的 H AP微毬。通過XRD、IR、SEM、TEM對微毬進行瞭錶徵,研究瞭實驗條件對產物成分及形貌的影響。結果錶明,適宜的閤成條件為：反應溫度50℃,反應時間24 h,內水相pH 值≥10,在此條件下製備的產物為毬形 HAP 粒子,直徑分佈在50~200 nm 之間,呎吋比較均一,每箇微毬由大量的納米 H AP 粒子堆積而成,微毬呈現疏鬆多孔結構。這種多孔 H AP 微毬在骨組織脩複及藥物控釋材料方麵具有應用前景。
채용초성보조복유법제비다공 H AP 미구,통과조절반응온도、시간화 pH 치조건,획득료립경분포균균、형모규칙,구유불규칙납미다공결구적 H AP미구。통과XRD、IR、SEM、TEM대미구진행료표정,연구료실험조건대산물성분급형모적영향。결과표명,괄의적합성조건위：반응온도50℃,반응시간24 h,내수상pH 치≥10,재차조건하제비적산물위구형 HAP 입자,직경분포재50~200 nm 지간,척촌비교균일,매개미구유대량적납미 H AP 입자퇴적이성,미구정현소송다공결구。저충다공 H AP 미구재골조직수복급약물공석재료방면구유응용전경。
Porous hydroxyapatite(HAP)microspheres were prepared by a multiple emulsion method assisted by ultrasonic.With uniform size and irregular nano-pores of porous HAP microspheres were prepared by adj usting the factors of reaction temperature,time and pH value.The obtained microspheres were characterized using XRD,IR,SEM and TEM,and the experiment conditions on the product composition and morphology were studied.Results showed that the optimal temperature was 50 ℃,reaction time was 24 h,and the pH value of the inner water phase was over 10.The prepared HAP microspheres deposited with nano HAP particles are por-ous and have an average diameter of 50-200 nm.These porous HAP microspheres with an internal cavity are promising candidates for filler of skeletal defects and drug delivery.
