CAJ | 학술논문

目的：探讨已绝经女性精神分裂症合并高催乳素血症患者在合用与换用阿立哌唑时对其催乳素水平影响的对照研究。方法：对90例已绝经女性精神分裂症同时合并高催乳素血症的患者随机分为两组，合用组：45例，为原有药物联合阿立哌唑5mg／d治疗12周，换用组：45例，为原有药物更换为治疗剂量阿立哌唑（14．78±4．76mg／d）12周，治疗前和治疗后2、4、8、12周末分别测定催乳素水平并予以阳性和阴性量表（PANSS）和副反应量表（TESS）评定病情并进行比较。结果：根据重复测量结果，两组间PRL水平尚无统计学差异（ F＝3．507，P＝0．064），但组间检验提示时间、研究组别有交互作用（P＝0．002），即PRL的值受到时间和组别的共同影响。 PRL随着时间的推移逐渐下降，且换用组下降的幅度大于合用组。两组间PANSS量表总分无统计学差异（ F＝0．145，P＝0．705）。结论：无论合用阿立哌唑治疗组或是换用阿立哌唑治疗组，均能使已绝经女性精神分裂症患者的高催乳素水平下降，但换用阿立哌唑治疗，催乳素水平下降幅度更大。
목적：탐토이절경녀성정신분렬증합병고최유소혈증환자재합용여환용아립고서시대기최유소수평영향적대조연구。방법：대90례이절경녀성정신분렬증동시합병고최유소혈증적환자수궤분위량조，합용조：45례，위원유약물연합아립고서5mg／d치료12주，환용조：45례，위원유약물경환위치료제량아립고서（14．78±4．76mg／d）12주，치료전화치료후2、4、8、12주말분별측정최유소수평병여이양성화음성량표（PANSS）화부반응량표（TESS）평정병정병진행비교。결과：근거중복측량결과，량조간PRL수평상무통계학차이（ F＝3．507，P＝0．064），단조간검험제시시간、연구조별유교호작용（P＝0．002），즉PRL적치수도시간화조별적공동영향。 PRL수착시간적추이축점하강，차환용조하강적폭도대우합용조。량조간PANSS량표총분무통계학차이（ F＝0．145，P＝0．705）。결론：무론합용아립고서치료조혹시환용아립고서치료조，균능사이절경녀성정신분렬증환자적고최유소수평하강，단환용아립고서치료，최유소수평하강폭도경대。
Objective: To investigate the role of aripiprazole in prolactin ( PRL ) metabolism through comparing the PRL levels of the postmenopausal women with schizophrenia and hyperprolactinemia .Method:90 women with schizophrenia and hyperprolactinemia were randomly divided into 2 groups:group A with 45 cases, former drugs plus aripiprazole 5mg once a day for 12 weeks) and group B with 45 cases, Aripiprazole 14.78±4.76mg once a day for 12 weeks).Then examined the PRL levels at 5 time points:prior treatment, 2 weeks, 4 weeks, 8 weeks, 12 weeks and accomplished the PANSS scales at the time points stated above as well.Result:According to the result of repeated measures ANOVA , the PRL levels of the 2 groups had no significant differences ( F=3.507,P=0.064) and had interaction between the groups and time points ( P=0. 002), suggesting that PRL was influenced by different treatment of aripiprazole and time .The score of PAN-SS scales had no significant differences (F=0.145,P=0.705).Conclusion:Aripiprazole may down-regulate the expression of the PRL levels of women with schizophrenia and hyperprolactinemia .