山东医药
山東醫藥
산동의약
SHANDONG MEDICAL JOURNAL
2015年
4期
11-13
,共3页
宋冬梅%吕欣%刘涛%王宝山
宋鼕梅%呂訢%劉濤%王寶山
송동매%려흔%류도%왕보산
阻塞性呼吸睡眠暂停低通气综合征%N-乙酰天门冬氨酸/胆碱%感音神经性聋%磁共振氢质子波谱
阻塞性呼吸睡眠暫停低通氣綜閤徵%N-乙酰天門鼕氨痠/膽堿%感音神經性聾%磁共振氫質子波譜
조새성호흡수면잠정저통기종합정%N-을선천문동안산/담감%감음신경성롱%자공진경질자파보
obstructive sleep apnea hypopnea syndrome%N-acetyl aspartate/choline%sensorineural hearing loss%1 H magnetic resonance spectroscopy
目的：通过磁共振氢质子波谱（1H-MRS）检测阻塞性睡眠呼吸暂停低通气综合征（OSAHS）颞横回听皮层区的神经代谢产物N-乙酰天门冬氨酸／胆碱（ NAA／Cho ）变化情况，以寻找听力损伤的早期预警指标。方法随机抽取PSG确诊OSAHS患者80例，经纯音听阈筛查将OSAHS患者分为双侧耳聋组（n＝26）、单侧耳聋组（n＝15）以及单纯OSAHS组（n＝39），选择健康志愿者19例作为正常对照组，1 H-MRS检测上述各组双侧颞横回听皮层NAA／Cho的变化；利用ROC曲线下面积＞50％判定NAA／Cho作为早期提示OSAHS患者合并感音神经性听力损伤的特异度及灵敏度。结果与正常对照组比较，单、双侧耳聋组NAA／Cho降低（ P均＜0．05）；与单纯OSAHS组相比，单侧、双侧耳聋组NAA／Cho降低（P均＜0．05）；而单侧耳聋组患侧与自身健侧NAA／Cho比较无统计学差异（P＞0．05）；ROC曲线测定NAA／Cho曲线下面积为78％。结论颞横回听皮层区神经代谢产物NAA／Cho有可能作为提示OSAHS患者感音神经性听力损伤发生的早期预警指标。
目的：通過磁共振氫質子波譜（1H-MRS）檢測阻塞性睡眠呼吸暫停低通氣綜閤徵（OSAHS）顳橫迴聽皮層區的神經代謝產物N-乙酰天門鼕氨痠／膽堿（ NAA／Cho ）變化情況，以尋找聽力損傷的早期預警指標。方法隨機抽取PSG確診OSAHS患者80例，經純音聽閾篩查將OSAHS患者分為雙側耳聾組（n＝26）、單側耳聾組（n＝15）以及單純OSAHS組（n＝39），選擇健康誌願者19例作為正常對照組，1 H-MRS檢測上述各組雙側顳橫迴聽皮層NAA／Cho的變化；利用ROC麯線下麵積＞50％判定NAA／Cho作為早期提示OSAHS患者閤併感音神經性聽力損傷的特異度及靈敏度。結果與正常對照組比較，單、雙側耳聾組NAA／Cho降低（ P均＜0．05）；與單純OSAHS組相比，單側、雙側耳聾組NAA／Cho降低（P均＜0．05）；而單側耳聾組患側與自身健側NAA／Cho比較無統計學差異（P＞0．05）；ROC麯線測定NAA／Cho麯線下麵積為78％。結論顳橫迴聽皮層區神經代謝產物NAA／Cho有可能作為提示OSAHS患者感音神經性聽力損傷髮生的早期預警指標。
목적：통과자공진경질자파보（1H-MRS）검측조새성수면호흡잠정저통기종합정（OSAHS）섭횡회은피층구적신경대사산물N-을선천문동안산／담감（ NAA／Cho ）변화정황，이심조은력손상적조기예경지표。방법수궤추취PSG학진OSAHS환자80례，경순음은역사사장OSAHS환자분위쌍측이롱조（n＝26）、단측이롱조（n＝15）이급단순OSAHS조（n＝39），선택건강지원자19례작위정상대조조，1 H-MRS검측상술각조쌍측섭횡회은피층NAA／Cho적변화；이용ROC곡선하면적＞50％판정NAA／Cho작위조기제시OSAHS환자합병감음신경성은력손상적특이도급령민도。결과여정상대조조비교，단、쌍측이롱조NAA／Cho강저（ P균＜0．05）；여단순OSAHS조상비，단측、쌍측이롱조NAA／Cho강저（P균＜0．05）；이단측이롱조환측여자신건측NAA／Cho비교무통계학차이（P＞0．05）；ROC곡선측정NAA／Cho곡선하면적위78％。결론섭횡회은피층구신경대사산물NAA／Cho유가능작위제시OSAHS환자감음신경성은력손상발생적조기예경지표。
Objective To explore the changes of NAA/Cho in transverse temporal gyrus with 1 H-MRS in obstructive sleep apnea hypopnea syndrome ( OSAHS) patients for looking for early warning indicators of hearing damage .Methods 80 patients with OSAHS confirmed by PSG were divided into bilateral deafness group (n =26), unilateral deafness group(n =15) and simple OSAHS group (n =39); 19 healthy volunteers were as normal control group .1 H-MRS was used todetect NAA/Cho in transverse temporal gyrus of the above groups , then compared with each group; the area under ROCcurve of >50% was used to judge the specificity and sensitivity of NAA /Cho as early tips for OSAHS patients with sensorineuralhearing loss.Results Compared with normal control group, OSAHS with (bilateral and unilateral) deafness groupsauditory cortex NAA/Cho decreased (all P <0.05); compared with the simple OSAHS group, OSAHS groups with (bilateraland unilateral) deafness NAA /Cho also decreased (all P <0.05); while there was no significant difference betweenipsilateral and contralateral transverse temporal gyrus in unilateral deafness OSAHS group (P >0.05).The area of NAA/Cho under the ROC curve was 78%.Conclusion In transverse temporal gyrus, nerve metabolites cortex NAA /Cho mayserve as early warning indicator to prompt OSAHS patients with sensorineural hearing damage occur .
