CAJ | 학술논문

目的：检验经鼻持续正压通气对新生儿肺透明膜病（HMD）的治疗效果。方法选取2010年7月至2013年7月在湖北医药学院附属东风医院就诊的HMD患儿64例作为研究对象，男40例，女24例，所有患儿均在出生2h内转入湖北医药学院附属东风医院接受治疗。将64例患儿分为两组，每组32例。两组患儿均给予常规的基础治疗，通气组另采用小儿呼吸机进行经鼻的持续正压通气治疗，观察两组患儿治疗后住院时间、并发症发生率、肺部感染率、持续肺泡内正压参数变化、两组患儿吸入氧分数参数变化和血气分析参数。结果两组患儿的基本资料比较差异无统计学意义（P＞0．05）。两组患儿治愈例数、住院时间、持续肺泡内正压参数、吸入氧分数参数和血气分析参数比较差异有统计学意义（P＜0．05）。结论经鼻持续正压通气对HMD在常规治疗的基础上可以达到良好的治疗效果，但是容易出现肺部并发症。
목적：검험경비지속정압통기대신생인폐투명막병（HMD）적치료효과。방법선취2010년7월지2013년7월재호북의약학원부속동풍의원취진적HMD환인64례작위연구대상，남40례，녀24례，소유환인균재출생2h내전입호북의약학원부속동풍의원접수치료。장64례환인분위량조，매조32례。량조환인균급여상규적기출치료，통기조령채용소인호흡궤진행경비적지속정압통기치료，관찰량조환인치료후주원시간、병발증발생솔、폐부감염솔、지속폐포내정압삼수변화、량조환인흡입양분수삼수변화화혈기분석삼수。결과량조환인적기본자료비교차이무통계학의의（P＞0．05）。량조환인치유례수、주원시간、지속폐포내정압삼수、흡입양분수삼수화혈기분석삼수비교차이유통계학의의（P＜0．05）。결론경비지속정압통기대HMD재상규치료적기출상가이체도량호적치료효과，단시용역출현폐부병발증。
Objective To evaluate nasal continuous positive airway pressure treatment for newborns with hya‐line membrane disease(HMD). Methods Totally 64 cases of children with HMD from July 2010 to July 2013 in the hospital as the research objects, including 40 cases of male patients, 24 cases of female patients, all patients were transferred to our hospital within 2 h of birth for treatment. All 64 cases were divided into two groups, 32 cases in each group. Two groups of children were given conventional treatment basis, pediatric breathing machine was adopted to improve the ventilation group via nasal continuous positive airway pressure treatment. The hospitalization time af‐ter treatment, incidence of complications, pulmonary infection, persistent alveolar positive parameters, two groups of children inspired oxygen fraction parameters, blood gas analysis parameters were observed. Results The basic infor‐mation of two groups of children with no significant difference (P>0. 05). The number of cured cases, hospitalization time, complication rates, persistent alveolar positive parameters, fraction of inspired oxygen parameters and blood gas analysis parameters were statistically significant (P<0. 05). Conclusion Nasal continuous positive airway pressure for newborns with HMD on the basis of conventional therapy can achieve good therapeutic effect, but prone to have pulmonary complications.