黑龙江医学
黑龍江醫學
흑룡강의학
HEILONGJIANG MEDICAL JOURNAL
2015年
1期
3-4,5
,共3页
高危型人乳头状瘤病毒%病毒载量%宫颈病变%病理
高危型人乳頭狀瘤病毒%病毒載量%宮頸病變%病理
고위형인유두상류병독%병독재량%궁경병변%병리
High risk HPV%Viral load%Cervical lesion%Pathology
目的：探讨宫颈病变不同级别与高危人乳头瘤病毒（ HPV）病毒载量的关系。方法选择2012－09～2014－07间广东省佛山市顺德伦教医院妇科门诊与广东省第二中医院治未病中心、妇科门诊进行宫颈病变筛查的女性1748例，给予高危HPV－DNA检测及阴道镜下多点活组织检查，以病理结果为参照标准，比较不同宫颈病变病理的高危 HPV－DNA阳性检出率，并采用 lo-gistic回归方法对高危HPV病毒载量与宫颈不同级别病变的关系进行分析。结果在1748例受检者中，病理结果为正常或炎性反应1368例，CIN I 36例，CINⅡ38例，CINⅢ137例，浸润性宫颈癌169例，其HPV 的阳性率分别为20.0％、88.9％、86.8％、86.1％和87.0％。正常或良性疾病组、CIN和浸润性宫颈癌患者高危型HPV阳性检出率之间差异有统计学意义（P ＜0.05），采用校正α＝0.005／3＝0.017检验水平，CIN和浸润性宫颈癌患者与正常或良性病变组高危型HPV阳性检出率之间差异均有统计学意义（ P＜0.05）。回归分析结果高危型HPV 病毒载量与宫颈病变级数呈正相关。结论不同宫颈病变高危HPV病毒载量有差别，宫颈病变风险随病毒载量增加而增加。
目的：探討宮頸病變不同級彆與高危人乳頭瘤病毒（ HPV）病毒載量的關繫。方法選擇2012－09～2014－07間廣東省彿山市順德倫教醫院婦科門診與廣東省第二中醫院治未病中心、婦科門診進行宮頸病變篩查的女性1748例，給予高危HPV－DNA檢測及陰道鏡下多點活組織檢查，以病理結果為參照標準，比較不同宮頸病變病理的高危 HPV－DNA暘性檢齣率，併採用 lo-gistic迴歸方法對高危HPV病毒載量與宮頸不同級彆病變的關繫進行分析。結果在1748例受檢者中，病理結果為正常或炎性反應1368例，CIN I 36例，CINⅡ38例，CINⅢ137例，浸潤性宮頸癌169例，其HPV 的暘性率分彆為20.0％、88.9％、86.8％、86.1％和87.0％。正常或良性疾病組、CIN和浸潤性宮頸癌患者高危型HPV暘性檢齣率之間差異有統計學意義（P ＜0.05），採用校正α＝0.005／3＝0.017檢驗水平，CIN和浸潤性宮頸癌患者與正常或良性病變組高危型HPV暘性檢齣率之間差異均有統計學意義（ P＜0.05）。迴歸分析結果高危型HPV 病毒載量與宮頸病變級數呈正相關。結論不同宮頸病變高危HPV病毒載量有差彆，宮頸病變風險隨病毒載量增加而增加。
목적：탐토궁경병변불동급별여고위인유두류병독（ HPV）병독재량적관계。방법선택2012－09～2014－07간광동성불산시순덕륜교의원부과문진여광동성제이중의원치미병중심、부과문진진행궁경병변사사적녀성1748례，급여고위HPV－DNA검측급음도경하다점활조직검사，이병리결과위삼조표준，비교불동궁경병변병리적고위 HPV－DNA양성검출솔，병채용 lo-gistic회귀방법대고위HPV병독재량여궁경불동급별병변적관계진행분석。결과재1748례수검자중，병리결과위정상혹염성반응1368례，CIN I 36례，CINⅡ38례，CINⅢ137례，침윤성궁경암169례，기HPV 적양성솔분별위20.0％、88.9％、86.8％、86.1％화87.0％。정상혹량성질병조、CIN화침윤성궁경암환자고위형HPV양성검출솔지간차이유통계학의의（P ＜0.05），채용교정α＝0.005／3＝0.017검험수평，CIN화침윤성궁경암환자여정상혹량성병변조고위형HPV양성검출솔지간차이균유통계학의의（ P＜0.05）。회귀분석결과고위형HPV 병독재량여궁경병변급수정정상관。결론불동궁경병변고위HPV병독재량유차별，궁경병변풍험수병독재량증가이증가。
Objective To explore the correlation of high risk HPV viral load and cervical lesion.Methods 1748 women were selected and detected by high risk -HPV-DNA detection and multipoint biopsy under colposcopy for screening cervical lesions from Sep , 2012 to July, 2014 in the hospital.Through pathology results being served as a reference , high-risk HPV-DNA positive detection rates of different cervical lesions were compared.The relationship between high risk HPV virus load and cervical lesions of different levels were analyzed by Logistic regression method.Results There were 1368 cases of normal or inflammation , 36 cases of cervical intraepithelial neoplasiaⅠ( CINⅠ) , 38 cases of CINⅡ, 137 cases of CINⅢand 169 cases of infiltrating carcinoma in 1748 cases.The positive rates of HPV of CINⅠ, CINⅡ, CINⅢand infiltrating carcinoma were 20.0%, 88.9%, 86.8%, 86.1%and 87.0%respectively.There were significant differences between normal or inflammation , CIN and infiltrating carcinoma ( P<0.05 ).The correction of α=0.005/3=0.017 test was adopted.There were significant differences between normal or inflammation and CIN , so were normal or inflammation and infiltrating carcinoma ( P<0.05 ).The results of regression analysis of high -risk HPV viral load were positively correlated with the level of cervical le-sions.C onclusion There are different grades of the high -risk HPV viral load and the risk of cervical lesions increases with viral load.
