CAJ | 학술논문

新一代高通量测序技术的发展，推动了多个相关研究领域的发展。国际上许多研究机构正在研究利用高通量测序数据进行微生物检测的算法，目前已有一些基于高通量测序数据的微生物检测算法流程设计成功并公开发布。该文通过调研利用高通量测序数据进行微生物检测的相关文献，研究已发布的基于高通量测序数据的微生物检测算法的功能和实现流程，分析几个有代表性算法的优点和不足。最后，对这些检测算法的设计思路进行总结和分类，提出基于高通量测序数据的微生物检测算法的改进设想。
신일대고통량측서기술적발전，추동료다개상관연구영역적발전。국제상허다연구궤구정재연구이용고통량측서수거진행미생물검측적산법，목전이유일사기우고통량측서수거적미생물검측산법류정설계성공병공개발포。해문통과조연이용고통량측서수거진행미생물검측적상관문헌，연구이발포적기우고통량측서수거적미생물검측산법적공능화실현류정，분석궤개유대표성산법적우점화불족。최후，대저사검측산법적설계사로진행총결화분류，제출기우고통량측서수거적미생물검측산법적개진설상。
The development of high throughput sequencing technology has promoted the development of many related spheres of research .Many research institutions are studying algorithms of microorganism detection using high throughput se -quencing data .Some algorithms have already been designed and published .In this paper , we investigated the literature re-garding the use of high throughput sequencing data for microorganism detection , studied the function and workflow of four released algorithms of microorganism detection based on high throughput sequencing data , and analyzed their advantages and disadvantages.Finally, we summarized how these detection algorithms were designed and classified them before we proposed ways of improvement .