CAJ | 학술논문

目的：分析重度子痫前期产妇脐血脂联素与新生儿结局的相关性。方法前瞻性收集2012年6月-2013年12月本院收治的重度子痫前期产妇分娩的新生儿100例为观察组，同期健康产妇分娩的新生儿100例为对照组，新生儿娩出后立即取脐静脉血检测血清脂联素，分析脐血脂联素含量与新生儿出生结局（早产、低出生体质量及其并发症如呼吸窘迫综合征、羊水吸入综合征或湿肺、脑损伤如缺氧缺血性脑病、颅内出血等）的相关性。结果观察组脐血脂联素含量与对照组比较，差异有统计学意义（t=20.05，P＜0.01）；观察组早产儿、低体重儿、窒息、低血糖症、羊水吸入综合征、RDS的发生均比对照组高，差异均有统计学意义（P均＜0.05），高胆红素血症、ICH两组比较差异均无统计学意义（P均＞0.05）；脐血脂联素含量与早产儿出生体重呈正相关（r=0.432，P＜0.05），与新生儿低血糖症患儿血糖值及高胆红素血症患儿经皮胆红素值均无相关性（r分别为0.593及-0.439，P均＞0.05）。结论重度子痫前期产妇脐血脂联素可能在胎儿生长发育过程中起重要的调节作用，与新生儿出生结局密切相关。
목적：분석중도자간전기산부제혈지련소여신생인결국적상관성。방법전첨성수집2012년6월-2013년12월본원수치적중도자간전기산부분면적신생인100례위관찰조，동기건강산부분면적신생인100례위대조조，신생인면출후립즉취제정맥혈검측혈청지련소，분석제혈지련소함량여신생인출생결국（조산、저출생체질량급기병발증여호흡군박종합정、양수흡입종합정혹습폐、뇌손상여결양결혈성뇌병、로내출혈등）적상관성。결과관찰조제혈지련소함량여대조조비교，차이유통계학의의（t=20.05，P＜0.01）；관찰조조산인、저체중인、질식、저혈당증、양수흡입종합정、RDS적발생균비대조조고，차이균유통계학의의（P균＜0.05），고담홍소혈증、ICH량조비교차이균무통계학의의（P균＞0.05）；제혈지련소함량여조산인출생체중정정상관（r=0.432，P＜0.05），여신생인저혈당증환인혈당치급고담홍소혈증환인경피담홍소치균무상관성（r분별위0.593급-0.439，P균＞0.05）。결론중도자간전기산부제혈지련소가능재태인생장발육과정중기중요적조절작용，여신생인출생결국밀절상관。
Objective To analyze the relation that the adiponectin level in umbilical cord blood with the neonatal outcomes of severe pre-eclampsia mothers. Methods It was a prospective study of 100 neonatal cases of severe pre-eclampsia as observation group,collected from June 2012 to December 2013 in our hospital,and 100 neonatal cases of healthy mothers in the same term as control group. We collected umbilical cord blood after the neonates delivered,tested the adiponectin level in it,discussed the cor-relation between the adiponectin level in umbilical cord blood ,and the relation that the adiponectin level to the neonatal outcomes of severe pre-eclampsia (including premature,lower birth weigh and its complication such as respiratory distress syndrom,aspira-tion of amniotic fluid syndrome or wet lung,brain injury like hypoxicischemic encephalopathy and intracranial hemorrhage et al). Results We contrasted the level of adiponectin of observation group and control group ,the difference was statistically significant (t value of 20.05,P<0.01). The occurrence of premature,lower birth weigh,asphyxia,hypoglycemia,aspiration of amniotic fluid syn-drome and respiratory distress syndrom in observation group were higher than those in control group ,the difference was all statisti-cally significant (P<0.05). The difference of hyperbilirubinemia and intracranial hemorrhage between the two groups had no signifi-cant(P>0.05). There was a positive correlation between the adiponectin level and the birth weight of premature (r=0.432,P<0.05), but had no significant relation to the blood glucose level of neonatal hypoglycemia and percutaneous bilirubin value of hyper-bilirubinemia (r value of 0.593 and -0.439,P>0.05). Conclusion The adiponectin level in umbilical cord blood of severe pre-eclampsia may be play an important role in regulating in the process of fetal growth and development ,closely related to neonatal outcomes.