江西医药
江西醫藥
강서의약
JIANGXI MEDICAL JOURNAL
2015年
1期
13-15,61
,共4页
超长方案%拮抗剂方案%PCOS%OHSS
超長方案%拮抗劑方案%PCOS%OHSS
초장방안%길항제방안%PCOS%OHSS
Super long project%GnRH-antagnist project%PCOS%OHSS
目的：比较超长方案和拮抗剂方案在PCOS患者行体外受精-胚胎移植（IVF-ET）治疗中的治疗效果。方法选择2013年1月-12月在本院行第一次IVF-ET治疗的PCOS患者112例，行超长方案治疗患者61个周期为研究组，拮抗剂方案治疗患者51个周期为对照组。结果研究组的Gn天数，Gn总量明显高于对照组（P<0.05），差异有统计学意义；HCG日E2水平、获卵数、受精率、卵裂率、优胚率均无统计学差异（P>0.05）；移植日内膜厚度、种植率研究组显著高于对照组，有显著性差异（P<0.05）；HCG阳性率、临床妊娠率、OHSS发生率两组比较，虽然没有统计学差异，但研究组有明显升高的趋势；超长方案组全胚冷冻35例，未受精取消移植1例，其中因预防OHSS风险全胚冷冻30例，拮抗剂组全胚冷冻30例，胚胎发育差取消移植1例，因预防OHSS风险全胚冷冻13例。结论超长方案应用于PCOS患者，种植率和临床妊娠率明显高于拮抗剂方案，其获卵数和OHSS发生率并没有显著性差异，临床可以通过调整GN启动时间和启动剂量募集合适数量的卵泡并降低OHSS发生率，全胚冷冻也是预防OHSS风险的举措之一。
目的：比較超長方案和拮抗劑方案在PCOS患者行體外受精-胚胎移植（IVF-ET）治療中的治療效果。方法選擇2013年1月-12月在本院行第一次IVF-ET治療的PCOS患者112例，行超長方案治療患者61箇週期為研究組，拮抗劑方案治療患者51箇週期為對照組。結果研究組的Gn天數，Gn總量明顯高于對照組（P<0.05），差異有統計學意義；HCG日E2水平、穫卵數、受精率、卵裂率、優胚率均無統計學差異（P>0.05）；移植日內膜厚度、種植率研究組顯著高于對照組，有顯著性差異（P<0.05）；HCG暘性率、臨床妊娠率、OHSS髮生率兩組比較，雖然沒有統計學差異，但研究組有明顯升高的趨勢；超長方案組全胚冷凍35例，未受精取消移植1例，其中因預防OHSS風險全胚冷凍30例，拮抗劑組全胚冷凍30例，胚胎髮育差取消移植1例，因預防OHSS風險全胚冷凍13例。結論超長方案應用于PCOS患者，種植率和臨床妊娠率明顯高于拮抗劑方案，其穫卵數和OHSS髮生率併沒有顯著性差異，臨床可以通過調整GN啟動時間和啟動劑量募集閤適數量的卵泡併降低OHSS髮生率，全胚冷凍也是預防OHSS風險的舉措之一。
목적：비교초장방안화길항제방안재PCOS환자행체외수정-배태이식（IVF-ET）치료중적치료효과。방법선택2013년1월-12월재본원행제일차IVF-ET치료적PCOS환자112례，행초장방안치료환자61개주기위연구조，길항제방안치료환자51개주기위대조조。결과연구조적Gn천수，Gn총량명현고우대조조（P<0.05），차이유통계학의의；HCG일E2수평、획란수、수정솔、란렬솔、우배솔균무통계학차이（P>0.05）；이식일내막후도、충식솔연구조현저고우대조조，유현저성차이（P<0.05）；HCG양성솔、림상임신솔、OHSS발생솔량조비교，수연몰유통계학차이，단연구조유명현승고적추세；초장방안조전배냉동35례，미수정취소이식1례，기중인예방OHSS풍험전배냉동30례，길항제조전배냉동30례，배태발육차취소이식1례，인예방OHSS풍험전배냉동13례。결론초장방안응용우PCOS환자，충식솔화림상임신솔명현고우길항제방안，기획란수화OHSS발생솔병몰유현저성차이，림상가이통과조정GN계동시간화계동제량모집합괄수량적란포병강저OHSS발생솔，전배냉동야시예방OHSS풍험적거조지일。
Objective To compare the application and effect of super long project and GnRH-antagnist in IVF-ET with the patiens of PCOS. Methods 112 patients with PCOS were selected and received IVF-ET in our hospital,who were randomly divid-ed into observation group(61cases) and control group(51cases),the observation group was usd super long project,the control group was used GnRH-antagnist project. Results The number of Gn days,the dosage of Gn,theendometrial thickness on the HCG in-jecting day,the implantation rate of the observation group were higher than those of control group,there were significiant differ-ence. There were no significiant difference between two groups in serum levels of E2,the number of eggs,the fertility rate,cleavage rate and premium embyo rate. The clinical rate and the rate of OHSS in the observation group were higher than that of control group but with no statistical significance. There were 35 cases freezing whole embryo in which there were 30 cases for preventing OHSS,and 1 cases Cancelled the transplant becuse of unfertilized in the observation group,There were 30 cases freezing whole embryo in which there were 13 cases for preventing OHSS,and 1 cases Cancelled the transplant becuse ofembryonic development is poor in the contr ol group. Conclusion Super long project in IVF-ET of patients with PCOS can improve the clinical pregnancy and implantation rate,but have no difference in the number of eggs and OHSS rate. we can ajust the day of start injecting Gn and the dosage of Gn to raising the right number of follicles and deduce the OHSS rate The whole embryo freezingIs also one of the measures to prevent OHSS risk.
