CAJ | 학술논문

选择（NH4）2 S2 O8为引发剂，N‐N′‐亚甲基双丙烯酰胺（MBA）为交联剂，十二烷基硫酸钠（SDS）为制孔剂，通过改变水凝胶膜的溶剂与单体的配比、交联剂和制孔剂的量等制备出不同性质的水凝胶膜，运用电镜扫描、含水率、电子拉力机等表征不同水凝胶膜的性能．本研究尝试将硫酸新霉素药物作为载入药物导入水凝胶中，进行载药和缓释能力测试．实验结果表明，当单体甲基丙烯酸羟乙酯与水的比例为1∶3，引发剂过硫酸铵含量为单体1．0％（w ／V ），SDS 为4．0％（w ／V ），MBA 为4．0％（w ／V ）时，水凝胶的含水率为42．84％，拉伸强度为0．32 MPa ，药物缓释累积达峰时间为8．17 h ，综合性能较佳．
선택（NH4）2 S2 O8위인발제，N‐N′‐아갑기쌍병희선알（MBA）위교련제，십이완기류산납（SDS）위제공제，통과개변수응효막적용제여단체적배비、교련제화제공제적량등제비출불동성질적수응효막，운용전경소묘、함수솔、전자랍력궤등표정불동수응효막적성능．본연구상시장류산신매소약물작위재입약물도입수응효중，진행재약화완석능력측시．실험결과표명，당단체갑기병희산간을지여수적비례위1∶3，인발제과류산안함량위단체1．0％（w ／V ），SDS 위4．0％（w ／V ），MBA 위4．0％（w ／V ）시，수응효적함수솔위42．84％，랍신강도위0．32 MPa ，약물완석루적체봉시간위8．17 h ，종합성능교가．
In this work ,a drug‐carrying hydrogel membrane of poly‐hydroxy‐ethyl methacry‐late (PHEMA) was prepared by the use of monomer‐HEMA ,initiating agent‐(NH4 )2 S2 O8 , cross‐linking agent‐MBA ,pore‐foaming agent‐SDS and neomycin sulfate .The influence factor was researched by changing the ratio of solvents and monomer ,reaction temperature ,adding different amount of cross‐linking agent and pore‐foaming agent etc .The performance of the hy‐drogels was demonstrated with the electron microscope scanning ,moisture content ,electronic tensile machine ,infrared spectrometer ,fluorescence spectrophotometer etc .This paper tries to put neomycin sulfate medicine into hydrogels to test drug‐carrying and releasing performance . The experimental result shows that the moisture content ,tensile strength ,swelling degree of the hydrogel are 42 .84% ,0 .32 M Pa ,and the controlled‐release time of the neomycin sulfate is 8 .17 h when the ratio of HEMA and water is 1 to 3 ,the (NH4 )2 S2 O8 is 1 .0% ,the MBA is 4 .0% ,and the SDS is 4 .0% .