CAJ | 학술논문

磁场是磁性药物纳米粒子在微血管中输运的主要驱动力。在磁性药物靶向治疗系统中，磁粒子在磁场中被磁化，外磁场将对其产生吸引力，使其向磁场范围运动；同时被磁化的磁粒子之间将产生有效偶极子场，即附加磁场。考虑外磁场以及附加磁场的作用，推导出外磁场、附加磁场、外磁场力和附加磁场力的方程，通过数值模拟分析，讨论了磁场和磁力在微血管中的分布规律以及外磁介质参数对磁场强度和磁力的影响作用。研究结果显示，圆柱型永磁体能够产生较合适磁场强度和磁场梯度，以获得理想的靶向效果。
자장시자성약물납미입자재미혈관중수운적주요구동력。재자성약물파향치료계통중，자입자재자장중피자화，외자장장대기산생흡인력，사기향자장범위운동；동시피자화적자입자지간장산생유효우겁자장，즉부가자장。고필외자장이급부가자장적작용，추도출외자장、부가자장、외자장력화부가자장력적방정，통과수치모의분석，토론료자장화자력재미혈관중적분포규률이급외자개질삼수대자장강도화자력적영향작용。연구결과현시，원주형영자체능구산생교합괄자장강도화자장제도，이획득이상적파향효과。
Magnetic field is a major power source of magnetic nanoparticle transport in microvessel. In the magnetic drug targeting therapy system,the magnetic nanoparticles are magnetized in the magnetic field and attracted within the range of the magnetic field. At the same time,an induced dipole- dipole interaction between the magnetic nanoparticles, namely the modifield magnetic field,come into existence. Considering both external and modifield magnetic fields, this paper simulates the distribution of the magnetic field and magnetic force and discusses their effects on the magnetic nanoparticle transport. Results show that the magnetic force is bigger as the distance between magnet and blood vessel is nearer.