CAJ | 학술논문

目的：观察左旋肉碱对脂肪肝患者血脂、肝酶、肝脂肪变、体脂的影响。方法：用自身对照法对某社区32名脂肪肝患者进行3个月的膳食干预。受试者保持原有饮食、生活习惯，每日服左旋肉碱片2次，每次2片。测量比较干预前后血脂、肝酶、体脂、肝脂肪变的变化。结果：3个月膳食干预后，受试者谷丙转氨酶（ALT）、谷草转氨酶（AST）、总胆红素（TBIL）、甘油三酯（TG）、胆固醇（TC）、低密度脂蛋白（LDL）分别较干预前也明显下降（P＜0.01），HDL较干预前也明显升高（P＜0.01），且受试者体质量、体脂指数、腰围、腹围、臀围、腰臀比分别较干预前明显下降（P＜0.01），对受试者皮下脂肪厚度（臂部、背部、腹部）分别较干预前也明显下降（P＜0.01），肝/脾比值明显升高（P＜0.01），并且试验过程中无不良反应产生。结论：以左旋肉碱作为膳食补充，可以调节脂肪肝患者血脂、降低肝酶、改善肝脂肪变性、减轻患者体质量，并且此法是方便可行、宜长期采用的营养干预方案。
목적：관찰좌선육감대지방간환자혈지、간매、간지방변、체지적영향。방법：용자신대조법대모사구32명지방간환자진행3개월적선식간예。수시자보지원유음식、생활습관，매일복좌선육감편2차，매차2편。측량비교간예전후혈지、간매、체지、간지방변적변화。결과：3개월선식간예후，수시자곡병전안매（ALT）、곡초전안매（AST）、총담홍소（TBIL）、감유삼지（TG）、담고순（TC）、저밀도지단백（LDL）분별교간예전야명현하강（P＜0.01），HDL교간예전야명현승고（P＜0.01），차수시자체질량、체지지수、요위、복위、둔위、요둔비분별교간예전명현하강（P＜0.01），대수시자피하지방후도（비부、배부、복부）분별교간예전야명현하강（P＜0.01），간/비비치명현승고（P＜0.01），병차시험과정중무불량반응산생。결론：이좌선육감작위선식보충，가이조절지방간환자혈지、강저간매、개선간지방변성、감경환자체질량，병차차법시방편가행、의장기채용적영양간예방안。
Objective: To investigate the effects of L-carnitine on regulating blood lipids, transaminase, hepatic steatosis and fatty of patients with fatty liver.Methods: Dietary intervention with self-control method was adopted in 32 patients with fatty liver living one community. All participants take plus two oral L-carnitine tablets twice a day for three months. Blood lipids, transaminase, hepatic steatosis and fatty prior to intervention were tested and compared to those of after intervention in all participants.Results: After 3 months’ dietary in-tervention, ALT, AST, TBIL, TG, TC, LDL of patients were signiifcantly decreased in contrast to those of prior intervention (P<0.01), while HDL was signiifcantly increased (P<0.01). Body weight, body fat index, waistline, abdominal circumference, hips, waist-hip ratio of all participants were decreasing (P<0.01), respectively, mean-while the subcutaneous fat thickness (arm, back, abdomen) also signiifcantly decreased in contrast to that of prior intervention (P<0.01). Moreover, liver/spleen ratio was signiifcantly increased after intervention (P<0.01), and no side effects was observed in all participants during the trial.Conclusion: As a dietary supplement, L-carnitine can improve the blood lipids, hepatic steatosis, reduce the patient’s transaminase and weight. The dietary inter-vention strategy is convenient and feasible for patients with fatty liver, and also easy for long-term use.