CAJ | 학술논문

目的：探讨阴道塞芬吗通和口服补佳乐两种内膜准备方式对复苏囊胚移植替代周期妊娠结局的影响。方法：回顾性分析2011年7月-2012年12月在本中心接受体外受精-胚胎移植（IVF-ET）治疗的280个囊胚解冻移植的周期，其中采用阴道塞芬吗通加黄体酮替代方案107例（A组），口服补佳乐加黄体酮替代方案173例（B组），比较两种内膜准备方式对复苏囊胚移植替代周期妊娠结局的影响。结果：孕激素转化前使用雌激素的时间A组为（9.80±2.81）d，B组为（10.84±4.12）d，使用雌激素剂量A组为（15.55±10.42） mg，B组为（58.80±24.57）mg，而孕激素转化日血雌二醇（E2）水平A组为（2955.58±1983.94）pmol/L， B组为（923.25±441.52）pmol/L，差异均有统计学意义（均P＜0.05）。每移植周期的临床妊娠率分别为57.94%（62/107）和55.49%（96/173），两者比较差异无统计学意义（P＞0.05）。2组的子宫内膜厚度、优质胚胎率、移植胚胎数、胚胎种植率、临床妊娠率、流产率、多胎发生率及异位妊娠率比较差异均无统计学意义（P＞0.05）。结论：在冻融胚胎移植（FET）替代周期中，与口服补佳乐比较，阴道塞芬吗通不影响妊娠结局，可以单独作为雌激素在复苏囊胚移植替代周期中应用。
목적：탐토음도새분마통화구복보가악량충내막준비방식대복소낭배이식체대주기임신결국적영향。방법：회고성분석2011년7월-2012년12월재본중심접수체외수정-배태이식（IVF-ET）치료적280개낭배해동이식적주기，기중채용음도새분마통가황체동체대방안107례（A조），구복보가악가황체동체대방안173례（B조），비교량충내막준비방식대복소낭배이식체대주기임신결국적영향。결과：잉격소전화전사용자격소적시간A조위（9.80±2.81）d，B조위（10.84±4.12）d，사용자격소제량A조위（15.55±10.42） mg，B조위（58.80±24.57）mg，이잉격소전화일혈자이순（E2）수평A조위（2955.58±1983.94）pmol/L， B조위（923.25±441.52）pmol/L，차이균유통계학의의（균P＜0.05）。매이식주기적림상임신솔분별위57.94%（62/107）화55.49%（96/173），량자비교차이무통계학의의（P＞0.05）。2조적자궁내막후도、우질배태솔、이식배태수、배태충식솔、림상임신솔、유산솔、다태발생솔급이위임신솔비교차이균무통계학의의（P＞0.05）。결론：재동융배태이식（FET）체대주기중，여구복보가악비교，음도새분마통불영향임신결국，가이단독작위자격소재복소낭배이식체대주기중응용。
Objective: To compare the effect of Femoston and Progynova applied in the hormone replace-ment cycle for frozen-thawed blastocyst transfer.Methods: Two hundred and eight blastocyst FET cycles were analyzed retrospectively from July 2011 to December 2012. All cases were divided into two groups: 107 Femo-ston plus progesterone protocol group (group A), 173 Progynova plus progesterone protocol group (group B). Patient’s age, basic endocrine, endometrial thickness on the day of progesterone initiation, mean dosage and dura-tion of estrogen per cycle, high quality embryo rate, mean number of embryo transferred per patient, implantation rate, clinical pregnancy rate, early abortion rate and ectopic pregnancy rate were compared between the two groups. Results: Before progesterone initiation, the duration of estrogen used in group A and group B was (9.80±2.81) d and (10.84±4.12) d and the dosage of estrogen used in group A and B was (15.55±10.42) mg and (58.80±24.57) mg respectively. The estradiol level on the day of progesterone initiation in group A and group B was (2 955.58± 1 983.94) pmol/L and (923.25±441.52) pmol/L, respectively. They all had signiifcant differences (P<0.05). Clinical pregnancy rate were 57.94% (62/107) and 55.49% (96/173), respectively, and there was no statistically signiifcant difference (P>0.05). Patient’s endometrial thickness on the day of progesterone initiation, high quality embryo rate, mean number of embryo transferred for per patient, implantation rate, clinical pregnancy rate, early abortion rate and ectopic pregnancy rate in these two groups had no signiifcant different (P>0.05).Conclusion: In hormone replacement cycle for frozen-thawed embryo transfer, the use of Femoston can obtain the similar pregnancy rate compared with Progynova. So Femoston can be used as estrogen alone in blastocyst transplant recovery cycle.