CAJ | 학술논문

目的：了解安徽滁州市第一人民医院临床分离常见革兰阴性杆菌的构成及耐药情况，为合理用药提供依据。方法回顾性分析2013年从各类临床标本中分离的革兰阴性杆菌的构成及耐药性。结果2013年共分离革兰阴性杆菌1060株，主要为大肠埃希菌、肺炎克雷伯菌、铜绿假单胞菌和鲍曼不动杆菌，分别占29．3％、22．8％、11．5％、9．9％。大肠埃希菌、肺炎克雷伯菌和奇异变性杆菌中产 ESBL 的检出率分别为63．7％、32．2％和28．0％。肠杆菌科细菌对美罗培南和亚胺培南较敏感。铜绿假单胞菌对美罗培南、亚胺培南、阿米卡星的耐药率均低于30％。不动杆菌属（鲍曼不动杆菌占70．9％）对美罗培南和亚胺培南的耐药率分别为25．0％和26．2％。结论2013年该院分离的革兰阴性杆菌耐药情况严重，应加强对其耐药性监测。
목적：료해안휘저주시제일인민의원림상분리상견혁란음성간균적구성급내약정황，위합리용약제공의거。방법회고성분석2013년종각류림상표본중분리적혁란음성간균적구성급내약성。결과2013년공분리혁란음성간균1060주，주요위대장애희균、폐염극뢰백균、동록가단포균화포만불동간균，분별점29．3％、22．8％、11．5％、9．9％。대장애희균、폐염극뢰백균화기이변성간균중산 ESBL 적검출솔분별위63．7％、32．2％화28．0％。장간균과세균대미라배남화아알배남교민감。동록가단포균대미라배남、아알배남、아미잡성적내약솔균저우30％。불동간균속（포만불동간균점70．9％）대미라배남화아알배남적내약솔분별위25．0％화26．2％。결론2013년해원분리적혁란음성간균내약정황엄중，응가강대기내약성감측。
Objective To investigate the distribution and antibiotic resistance of gram-negative bacilli for better antimicrobial therapy in our hospital.Methods A retrospective analysis was conducted for the 1 060 strains of gram-negative bacilli isolated from clinical specimens during 2013.Results Of the 1 060 gram-negative bacterial strains isolated during 2013,E.coli,K . pneumoniae,P .aeruginosa and A.baumannii were the leading pathogens,accounting for 29.3%,22.8%,11.5% and 9.9%,respectively.The prevalence of extended spectrum-lactamases (ESBLs)positive strains was 63.7%,32.2% and 28.0% in E.coli,K .pneumoniae and P .mirabilis,respectively.The Enterobacteriaceae strains were highly sensitive to carbapenems.The percentage of the P .aeruginosa isolates resistant to meropenem,imipenem or amikacin was lower than 30%.The percentage of the Acinetobacter spp.(A.baumannii accounted for 70.9%)strains resistant to meropenem and imipenem were 25.0% and 26.2%.Conclusions Most of the gram-negative bacilli are resistant to multiple antimicrobial agents. We should strengthen the monitoring of the antibiotic resistance of gram-negative bacilli and optimize antimicrobial therapy.