中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2015年
1期
32-34
,共3页
α1-AT%CRP%慢性阻塞性肺疾病
α1-AT%CRP%慢性阻塞性肺疾病
α1-AT%CRP%만성조새성폐질병
α1-AT%CRP%Chronic obstructive pulmonary diseases
目的：研究血清α1-AT及CRP水平检测在慢性阻塞性肺疾病（COPD）急性加重期患者中的临床意义。方法：将本院收治的64例AECOPD患者随机数字表法分为对照组和观察组，两组患者均给予基础治疗、雾化吸入沙丁胺醇和异丙托溴铵治疗。观察组在对照组治疗基础上，加用布地奈德雾化吸入治疗。治疗7 d后比较血清CRP和α1-AT水平，评定并比较临床疗效。结果：AECOPD组血清CRP显著高于COPD稳定期组（P<0.05），血清α1-AT水平与COPD稳定期组相当（P>0.05）。观察组和对照组患者治疗后CRP和α1-AT较治疗前均显著降低（P<0.05），观察组CRP降低幅度更大，治疗后CRP水平明显小于对照组（P<0.05），但两组之间α1-AT的差异比较无统计学意义（P>0.05）。结论：CRP可作为反应COPD病情严重程度的敏感性指标，联合与α1-AT检测，对COPD的诊断和疗效判断具有一定的临床应用价值。
目的：研究血清α1-AT及CRP水平檢測在慢性阻塞性肺疾病（COPD）急性加重期患者中的臨床意義。方法：將本院收治的64例AECOPD患者隨機數字錶法分為對照組和觀察組，兩組患者均給予基礎治療、霧化吸入沙丁胺醇和異丙託溴銨治療。觀察組在對照組治療基礎上，加用佈地奈德霧化吸入治療。治療7 d後比較血清CRP和α1-AT水平，評定併比較臨床療效。結果：AECOPD組血清CRP顯著高于COPD穩定期組（P<0.05），血清α1-AT水平與COPD穩定期組相噹（P>0.05）。觀察組和對照組患者治療後CRP和α1-AT較治療前均顯著降低（P<0.05），觀察組CRP降低幅度更大，治療後CRP水平明顯小于對照組（P<0.05），但兩組之間α1-AT的差異比較無統計學意義（P>0.05）。結論：CRP可作為反應COPD病情嚴重程度的敏感性指標，聯閤與α1-AT檢測，對COPD的診斷和療效判斷具有一定的臨床應用價值。
목적：연구혈청α1-AT급CRP수평검측재만성조새성폐질병（COPD）급성가중기환자중적림상의의。방법：장본원수치적64례AECOPD환자수궤수자표법분위대조조화관찰조，량조환자균급여기출치료、무화흡입사정알순화이병탁추안치료。관찰조재대조조치료기출상，가용포지내덕무화흡입치료。치료7 d후비교혈청CRP화α1-AT수평，평정병비교림상료효。결과：AECOPD조혈청CRP현저고우COPD은정기조（P<0.05），혈청α1-AT수평여COPD은정기조상당（P>0.05）。관찰조화대조조환자치료후CRP화α1-AT교치료전균현저강저（P<0.05），관찰조CRP강저폭도경대，치료후CRP수평명현소우대조조（P<0.05），단량조지간α1-AT적차이비교무통계학의의（P>0.05）。결론：CRP가작위반응COPD병정엄중정도적민감성지표，연합여α1-AT검측，대COPD적진단화료효판단구유일정적림상응용개치。
Objective: To observe the clinical effect alpha1-antitrypsin (α1-AT) and serum C reactive protein (CRP) levels in patients with acute exacerbation chronic obstructive pulmonary disease (COPD).Method: 64 patients with AECOPD in our hospital were chosen and divided randomly to observation group and control group, which all treated by basis treatment and pulverization inhalation treatment with salbutamol and ipratropium bromide. Patients in observation group were also given pulverization inhalation treatment of budesonide. The levels of serum CRP and α1-AT were compared after seven days treatment, and the clinical effects were evaluated and compared.Result: The CRP level of the AECOPD group was significantly higher than that of the stable COPD group (P<0.05), but the α1-AT level had no obviously differences between the two group (P>0.05). The levels of serum CRP and α1-AT significantly decreased after treatment, and the CRP level was significantly lower in observation group than that in the control group (P<0.05), while the α1-AT level between the two groups had no statistically significant differences (P>0.05).Conclusion: CRP is a sensitive indicator for the patients with COPD, combing with α1-AT associated detection, have clinical practical value for diagnose and therapeutic effect judging in COPD.
