中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2015年
1期
65-67,68
,共4页
许宇彪%李碧锦%何二松%林昌荣%莫凯迪
許宇彪%李碧錦%何二鬆%林昌榮%莫凱迪
허우표%리벽금%하이송%림창영%막개적
结肠癌%肝动脉置管泵化疗%肝转移%预防%生存分析
結腸癌%肝動脈置管泵化療%肝轉移%預防%生存分析
결장암%간동맥치관빙화료%간전이%예방%생존분석
Colorectal cancer%Hepatic arterial infusion pump chemotherapy%Liver metastasis%Prevention%Survival analysis
目的：评估结肠癌根治术后肝动脉置管泵化疗预防结肠癌肝转移价值。方法：将33例按手术治疗后无肝、肺、脑等远隔器官转移的结肠癌患者随机数字表法分为治疗组和对照组，治疗组术后行肝动脉置管泵化疗，对照组行经外周静脉穿刺中心静脉置管化疗，比较两组患者无肝转移生存时间。结果：治疗组平均无肝转移生存期为（24.2±4.3）个月，对照组平均无肝转移生存期为（16.6±2.0）个月，治疗组平均无肝转移生存期明显高于对照组，比较差异有统计学意义（t=4.562，P=0.041）；以肝转移为研究的终点事件，绘制两组的生存曲线，两组生存曲线比较差异具有统计学意义（Log-Rank 字2=25.085，P=0.000）。结论：相比常规经静脉化疗，结肠癌根治术后经肝动脉置管泵化疗能有效延缓结肠癌根治术后肝转移，是预防结肠癌肝转移的有效方法。
目的：評估結腸癌根治術後肝動脈置管泵化療預防結腸癌肝轉移價值。方法：將33例按手術治療後無肝、肺、腦等遠隔器官轉移的結腸癌患者隨機數字錶法分為治療組和對照組，治療組術後行肝動脈置管泵化療，對照組行經外週靜脈穿刺中心靜脈置管化療，比較兩組患者無肝轉移生存時間。結果：治療組平均無肝轉移生存期為（24.2±4.3）箇月，對照組平均無肝轉移生存期為（16.6±2.0）箇月，治療組平均無肝轉移生存期明顯高于對照組，比較差異有統計學意義（t=4.562，P=0.041）；以肝轉移為研究的終點事件，繪製兩組的生存麯線，兩組生存麯線比較差異具有統計學意義（Log-Rank 字2=25.085，P=0.000）。結論：相比常規經靜脈化療，結腸癌根治術後經肝動脈置管泵化療能有效延緩結腸癌根治術後肝轉移，是預防結腸癌肝轉移的有效方法。
목적：평고결장암근치술후간동맥치관빙화료예방결장암간전이개치。방법：장33례안수술치료후무간、폐、뇌등원격기관전이적결장암환자수궤수자표법분위치료조화대조조，치료조술후행간동맥치관빙화료，대조조행경외주정맥천자중심정맥치관화료，비교량조환자무간전이생존시간。결과：치료조평균무간전이생존기위（24.2±4.3）개월，대조조평균무간전이생존기위（16.6±2.0）개월，치료조평균무간전이생존기명현고우대조조，비교차이유통계학의의（t=4.562，P=0.041）；이간전이위연구적종점사건，회제량조적생존곡선，량조생존곡선비교차이구유통계학의의（Log-Rank 자2=25.085，P=0.000）。결론：상비상규경정맥화료，결장암근치술후경간동맥치관빙화료능유효연완결장암근치술후간전이，시예방결장암간전이적유효방법。
Objective: To evaluate the value of hepatic artery infusion pump chemotherapy for the prevention of liver metastasis after radical resection of colon cancer.Method: According to the different treatment methods, 33 cases without liver, lung, brain metastasis of distant organs in patients with colon cancer were randomly divided into treatment group and control group, the treatment group was treated with chemotherapy by hepatic artery infusion pump, while the control group underwent peripherally inserted central catheter chemotherapy, and the survival time without liver metastasis was compared.Result: In the treatment group, the average survival time without liver metastasis was (24.2±4.3) months, while in the control group, the average survival time without liver metastasis was (16.6±2.0) months. There were statistically significant differences between the two groups. The survival curves of the two groups by the endpoint of liver metastasis had statistically significant difference (Log-Rank χ2=25.085,P=0.000).Conclusion: Compared with the conventional intravenous chemotherapy, hepatic artery infusion pump chemotherapy after radical resection of colon cancer can effectively delay the liver metastasis after radical resection of colorectal cancer, and is a modus operandi for the prevention of liver metastases from colorectal cancer.
