中国医药指南
中國醫藥指南
중국의약지남
CHINA MEDICINE GUIDE
2015年
1期
22-23
,共2页
混其勒-7%抗炎镇痛%TNF-α
混其勒-7%抗炎鎮痛%TNF-α
혼기륵-7%항염진통%TNF-α
Hunqile-7%Anti-inflammatory and analgesic%Tumor necrosis factor-α(TNF-α)
目的：研究蒙药混其勒-7对小鼠的抗炎镇痛作用，初步探讨其作用机制。方法采用耳廓炎症肿胀实验测定其抗炎作用，热板痛阈和醋酸扭体实验测定其镇痛作用，ELISA法测定小鼠血清中肿瘤坏死因子α（tumor necrosis factor-α，TNF-α）的表达情况。结果中剂量混其勒-7可提高小鼠痛阈，减少扭体次数，并且改善二甲苯引发的炎症表现，其抗炎作用可能与TNF-α有关，而镇痛作用与TNF-α无关。结论混其勒-7具有抗炎镇痛作用，其抗炎作用可能与TNF-α有关。
目的：研究矇藥混其勒-7對小鼠的抗炎鎮痛作用，初步探討其作用機製。方法採用耳廓炎癥腫脹實驗測定其抗炎作用，熱闆痛閾和醋痠扭體實驗測定其鎮痛作用，ELISA法測定小鼠血清中腫瘤壞死因子α（tumor necrosis factor-α，TNF-α）的錶達情況。結果中劑量混其勒-7可提高小鼠痛閾，減少扭體次數，併且改善二甲苯引髮的炎癥錶現，其抗炎作用可能與TNF-α有關，而鎮痛作用與TNF-α無關。結論混其勒-7具有抗炎鎮痛作用，其抗炎作用可能與TNF-α有關。
목적：연구몽약혼기륵-7대소서적항염진통작용，초보탐토기작용궤제。방법채용이곽염증종창실험측정기항염작용，열판통역화작산뉴체실험측정기진통작용，ELISA법측정소서혈청중종류배사인자α（tumor necrosis factor-α，TNF-α）적표체정황。결과중제량혼기륵-7가제고소서통역，감소뉴체차수，병차개선이갑분인발적염증표현，기항염작용가능여TNF-α유관，이진통작용여TNF-α무관。결론혼기륵-7구유항염진통작용，기항염작용가능여TNF-α유관。
Objective To study the Mongolian Hunqile-7 anti-inflammatory and analgesic effect in mice, a preliminary explore its action mechanism. Methods Using auricle inflammation swelling experiments show its anti-inflammatory action, hot plate pain threshold and acetic acid twisting experiment measure its analgesic action, ELISA method for determination of mice serum tumor necrosis factor alpha(tumor necrosis factor-α, TNF-α)expression. Results Dose mixed in the Hunqile-7 can increase the pain threshold of mice, decrease the times of twisting the body and improve inflammation caused by xylene, its anti-inflammatory effects may be associated with the TNF-a, and analgesic action has nothing to do with the TNF-α.Conclusion Mix the anti-inflammatory and analgesic effects of Hunqile-7, its anti-inflammatory effects may be associated with the TNF-α.
