CAJ | 학술논문

目的：探讨更昔洛韦与其他药物联合治疗病毒性角膜炎的疗效。方法根据角膜病灶部位、深度分为两类。第一类100例：病变位于角膜上皮及浅基质层，分A、B两组。A组50例，单独应用更昔洛韦；B组50例，应用更昔洛韦联合其他药物。第二类106例：病变位于角膜深实质层或后弹力层及内皮层，分C、D两组。C组58眼，不用皮质类固醇激素；D组48眼，在配合应用抗生素的同时使用皮质类固醇激素。结果联合用药比单独用药效果好。应用皮质类固醇激素使病毒性角膜炎的复发率增加了19.8%。结论更昔洛韦与其他药物联合治疗病变位于角膜上皮及浅基质层的病毒性角膜炎疗效更好，起效更快，增进视力；应用皮质类固醇激素能增加病毒性角膜炎的复发率。
목적：탐토경석락위여기타약물연합치료병독성각막염적료효。방법근거각막병조부위、심도분위량류。제일류100례：병변위우각막상피급천기질층，분A、B량조。A조50례，단독응용경석락위；B조50례，응용경석락위연합기타약물。제이류106례：병변위우각막심실질층혹후탄력층급내피층，분C、D량조。C조58안，불용피질류고순격소；D조48안，재배합응용항생소적동시사용피질류고순격소。결과연합용약비단독용약효과호。응용피질류고순격소사병독성각막염적복발솔증가료19.8%。결론경석락위여기타약물연합치료병변위우각막상피급천기질층적병독성각막염료효경호，기효경쾌，증진시력；응용피질류고순격소능증가병독성각막염적복발솔。
ObjectivesTo investigate the therapeutic effect of ganciclovir combined with other drugs in treatment of viral keratitis.Method According to the depth of corneal lesion, the cases were divided into the first and the second classes. There were 100 cases in the first class. The cases of lesions located in the corneal epithelium and superficial stroma, were divided into A, B two groups. The 50 cases in group A used ganciclovir only. The 50 cases in group B used ganciclovir combined with other drugs. There were 106 cases in the second class, whose lesions were located in the corneal deep layer or the essence of descemet’s membrane and endothelium, who were divided into C, D two groups. There were 58 cases in group C which didn’t use corticosteroid. There were 48 cases in group D with the application of antibiotics used corticosteroid at the same time.Result Drug Combination is better than single drug. And the application of corticosteroid to viral keratitis recurrence rate increased 19.8%.Conclusion Gancilovir and other antiviral drugs treat viral keratitis whose lesions located in the corneal epithelium and superficial stroma, have better curative effect,work faster, and improve eyesight. The application of corticosteroid can increase the recurrence rate of viral keratitis.