中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2014年
36期
62-64
,共3页
脓毒血症%血小板参数%PAC-1%CD62P
膿毒血癥%血小闆參數%PAC-1%CD62P
농독혈증%혈소판삼수%PAC-1%CD62P
Sepsis%Platelet parameter%PAC-1%CD62P
目的：探讨脓毒血症患者血小板参数变化及其与血小板膜糖蛋白的关系，以寻求精确判断血小板功能状态的办法。方法：选取2013年2月-2014年1月于本院住院治疗的脓毒症患者48例为病例组，并选取同期健康体检者32例作为对照组，应用全自动血球分析仪检测血小板参数PC、MPV、PDW，采用流式细胞仪检测血小板膜糖蛋白PAC-1、CD62P的水平。结果：与对照组比较，病例组PC显著降低，MPV、PDW均显著增大，PAC-1、CD62P均表达上调，差异均有统计学意义（P<0.05）；Pearson相关性分析显示，MPV与PAC-1、CD62P表达水平均呈明显正相关（r=0.377、0.306，P<0.05），PV、PDW与PAC-1、CD62P表达水平之间无明显相关性（P>0.05）。结论：脓毒症患者体内存在血小板明显活化，血小板参数与血小板膜糖蛋白PAC-1、CD62P共同参与血小板活化过程。
目的：探討膿毒血癥患者血小闆參數變化及其與血小闆膜糖蛋白的關繫，以尋求精確判斷血小闆功能狀態的辦法。方法：選取2013年2月-2014年1月于本院住院治療的膿毒癥患者48例為病例組，併選取同期健康體檢者32例作為對照組，應用全自動血毬分析儀檢測血小闆參數PC、MPV、PDW，採用流式細胞儀檢測血小闆膜糖蛋白PAC-1、CD62P的水平。結果：與對照組比較，病例組PC顯著降低，MPV、PDW均顯著增大，PAC-1、CD62P均錶達上調，差異均有統計學意義（P<0.05）；Pearson相關性分析顯示，MPV與PAC-1、CD62P錶達水平均呈明顯正相關（r=0.377、0.306，P<0.05），PV、PDW與PAC-1、CD62P錶達水平之間無明顯相關性（P>0.05）。結論：膿毒癥患者體內存在血小闆明顯活化，血小闆參數與血小闆膜糖蛋白PAC-1、CD62P共同參與血小闆活化過程。
목적：탐토농독혈증환자혈소판삼수변화급기여혈소판막당단백적관계，이심구정학판단혈소판공능상태적판법。방법：선취2013년2월-2014년1월우본원주원치료적농독증환자48례위병례조，병선취동기건강체검자32례작위대조조，응용전자동혈구분석의검측혈소판삼수PC、MPV、PDW，채용류식세포의검측혈소판막당단백PAC-1、CD62P적수평。결과：여대조조비교，병례조PC현저강저，MPV、PDW균현저증대，PAC-1、CD62P균표체상조，차이균유통계학의의（P<0.05）；Pearson상관성분석현시，MPV여PAC-1、CD62P표체수평균정명현정상관（r=0.377、0.306，P<0.05），PV、PDW여PAC-1、CD62P표체수평지간무명현상관성（P>0.05）。결론：농독증환자체내존재혈소판명현활화，혈소판삼수여혈소판막당단백PAC-1、CD62P공동삼여혈소판활화과정。
Objective:To investigate the changes of platelet parameters in patients with sepsis and its relationship with Platelet membrane glycoprotein, in order to estimate accurately the function of platelet.Method:48 patients with sepsis treated in our hospital from February 2013 to January 2014 were selected as sepsis group, and 32 healthy subjects were selected as control group, the platelet parameters PC, MPV, PDW were detected with automatic blood cell analyzer, and the platelet membrane glycoprotein PAC-1, CD62P were detected with flow cytometry.Result:Compared with the control group, PC of the sepsis group was significantly decreased, MPV, PDW were significantly increased, the expression of PAC-1, CD62P were upregulated,there were statistically significant difference between the two groups (P<0.05). Pearson correlation analysis showed that, there were a significant positive correlation between MPV and the expression of PAC-1, CD62P(r=0.377,0.306,P<0.05),and non significant correlation between PDW, PV and the expression of PAC-1, CD62P(P<0.05).Conclusion:Platelet was activated in patient with sepsis, and platelet parameters and platelet membrane glycoprotein PAC-1, CD62P pay a role in the pathological process.
