中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2014年
36期
1-3
,共3页
卢妙%洪牮%王森
盧妙%洪牮%王森
로묘%홍천%왕삼
左室舒张功能%羧甲基赖氨酸%非酶糖基化
左室舒張功能%羧甲基賴氨痠%非酶糖基化
좌실서장공능%최갑기뢰안산%비매당기화
Left ventricular diastolic function%Serum carboxymethyl%Non-enzymatic glycosylation
目的:研究老年糖尿病患者羧甲基赖氨酸(CML)水平与血管硬化及左心室舒张功能减退的关系。方法:选取2013年12月-2014年8月本院住院的老年糖尿病患者116例,应用ELISA法检测血浆CML水平;多普勒超声心动仪测量左心室舒张早期血流速度(E)、舒张晚期血流速度(A),并计算出E/A,组织多普勒测量舒张早期运动速度峰值(E’),计算舒张早期血流速度与瓣环运动速度比值E/E’;用全自动动脉硬化测量仪测定动脉搏波传导速度(PWV)。结果:单因素分析显示,CML、年龄与baPWV、E/E’均呈正相关(P<0.05);与E/A呈负相关(P<0.05)。多元回归分析显示,CML与baPWV、E/E’呈正相关(P<0.01);CML与E/A呈显著负相关(P<0.01)。结论:老年糖尿病人群CML水平的升高导致左室舒张功能下降;降低糖基化终末产物的生成可以作为改善患者左室舒张功能的一种干预手段。
目的:研究老年糖尿病患者羧甲基賴氨痠(CML)水平與血管硬化及左心室舒張功能減退的關繫。方法:選取2013年12月-2014年8月本院住院的老年糖尿病患者116例,應用ELISA法檢測血漿CML水平;多普勒超聲心動儀測量左心室舒張早期血流速度(E)、舒張晚期血流速度(A),併計算齣E/A,組織多普勒測量舒張早期運動速度峰值(E’),計算舒張早期血流速度與瓣環運動速度比值E/E’;用全自動動脈硬化測量儀測定動脈搏波傳導速度(PWV)。結果:單因素分析顯示,CML、年齡與baPWV、E/E’均呈正相關(P<0.05);與E/A呈負相關(P<0.05)。多元迴歸分析顯示,CML與baPWV、E/E’呈正相關(P<0.01);CML與E/A呈顯著負相關(P<0.01)。結論:老年糖尿病人群CML水平的升高導緻左室舒張功能下降;降低糖基化終末產物的生成可以作為改善患者左室舒張功能的一種榦預手段。
목적:연구노년당뇨병환자최갑기뢰안산(CML)수평여혈관경화급좌심실서장공능감퇴적관계。방법:선취2013년12월-2014년8월본원주원적노년당뇨병환자116례,응용ELISA법검측혈장CML수평;다보륵초성심동의측량좌심실서장조기혈류속도(E)、서장만기혈류속도(A),병계산출E/A,조직다보륵측량서장조기운동속도봉치(E’),계산서장조기혈류속도여판배운동속도비치E/E’;용전자동동맥경화측량의측정동맥박파전도속도(PWV)。결과:단인소분석현시,CML、년령여baPWV、E/E’균정정상관(P<0.05);여E/A정부상관(P<0.05)。다원회귀분석현시,CML여baPWV、E/E’정정상관(P<0.01);CML여E/A정현저부상관(P<0.01)。결론:노년당뇨병인군CML수평적승고도치좌실서장공능하강;강저당기화종말산물적생성가이작위개선환자좌실서장공능적일충간예수단。
Objective:To observe the relevance of serum carboxymethyl with arterial stiffness and left ventricular diastolic function in elderly patients with type 2 diabetes.Method:116 elderly patients with type 2 diabetes from December 2013 to August 2014 in our hospital, and ELISA was applied to measure serum CML. The maximal velocity of mitral flow E peak and A were tested by two-dimensional echocardiography. The maximal speed of mitral flow E’ was measured by tissue Doppler.The E/A and E/E’ were calculated. The pulse wave velocity(PWV) was measured by Auto-survey atherosclerosis apparatus.Result:CML and age were positively correlated to baPWV and E/E’ by the univariate analysis (P<0.05). CML and age were negatively correlated to E/A(P<0.05).The multiple regression analysis showed CML was positively correlated to baPWV and E/E’ (P<0.01),while it was negatively correlated to E/A(P<0.01).Conclusion:CML is associated with increased arterial stiffness and decreased diastolic function in elderly patients with type 2 Diabetes. An treatment to decreasing advanced glycation end-product(AGEs)may be used to lower arterial stiffness and improve diastolic function.pulse wave velocity(PWV).