中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2014年
35期
124-126
,共3页
浆细胞瘤%多发性骨髓瘤%放射治疗
漿細胞瘤%多髮性骨髓瘤%放射治療
장세포류%다발성골수류%방사치료
Solitary plasmacytoma%Multiple myeloma%Radiotherapy
目的:回顾分析2004年-2013年本院接受放射治疗的21例孤立性浆细胞瘤患者的疗效。方法:21例接受放射治疗的孤立性浆细胞瘤患者中,18例随访完整。10例患者骨孤立性浆细胞瘤(SBP),8例患者为髓外浆细胞瘤(EP)。8例患者采用放射治疗为主的治疗,其他10例为部分切除术或脊柱减压后放疗。局部放疗中位剂量46 Gy(30~50.4 Gy),分割剂量1.8~2.0 Gy。结果:随访期间共2例患者局部复发率,SBP和EP各1例。全组5年和10总生存率均为77.8%,SBP组与EP组间总生存率无显著差异(P>0.05)。SBP和EP的5年无转化多发性骨髓瘤生存率有显著差异,分别为36.8%和86.7%(P=0.015)。结论:孤立性浆细胞瘤放射治疗的疗效好。而进展为多发性骨髓瘤,特别是骨孤立性浆细胞瘤,仍然是有待进一步研究。
目的:迴顧分析2004年-2013年本院接受放射治療的21例孤立性漿細胞瘤患者的療效。方法:21例接受放射治療的孤立性漿細胞瘤患者中,18例隨訪完整。10例患者骨孤立性漿細胞瘤(SBP),8例患者為髓外漿細胞瘤(EP)。8例患者採用放射治療為主的治療,其他10例為部分切除術或脊柱減壓後放療。跼部放療中位劑量46 Gy(30~50.4 Gy),分割劑量1.8~2.0 Gy。結果:隨訪期間共2例患者跼部複髮率,SBP和EP各1例。全組5年和10總生存率均為77.8%,SBP組與EP組間總生存率無顯著差異(P>0.05)。SBP和EP的5年無轉化多髮性骨髓瘤生存率有顯著差異,分彆為36.8%和86.7%(P=0.015)。結論:孤立性漿細胞瘤放射治療的療效好。而進展為多髮性骨髓瘤,特彆是骨孤立性漿細胞瘤,仍然是有待進一步研究。
목적:회고분석2004년-2013년본원접수방사치료적21례고립성장세포류환자적료효。방법:21례접수방사치료적고립성장세포류환자중,18례수방완정。10례환자골고립성장세포류(SBP),8례환자위수외장세포류(EP)。8례환자채용방사치료위주적치료,기타10례위부분절제술혹척주감압후방료。국부방료중위제량46 Gy(30~50.4 Gy),분할제량1.8~2.0 Gy。결과:수방기간공2례환자국부복발솔,SBP화EP각1례。전조5년화10총생존솔균위77.8%,SBP조여EP조간총생존솔무현저차이(P>0.05)。SBP화EP적5년무전화다발성골수류생존솔유현저차이,분별위36.8%화86.7%(P=0.015)。결론:고립성장세포류방사치료적료효호。이진전위다발성골수류,특별시골고립성장세포류,잉연시유대진일보연구。
Objective:To evaluate retrospectively the clinical effect of local radiotherapy for 21 patients with solitary plasmacytoma between 2004 and 2013. Method:Among these 21 patients,18 patients followed completely were analyzed .Ten patients suffered from solitary plasmacytoma of bone(SBP),and eight patients from extra-medullary plasmacytoma(EP). Eight cases were treated by radiation only ,the other ten cases were treated by radiation post-operatively. Radiotherapy with a median dose of radiation was 46 Gy(30-50.4 Gy)with fraction of 1.8-2.0 Gy.Result:Excellent local control with only two patient suffering from local relapse was yielded. Both 5-years and 10-years over-all survival rate were similarily 77.8%. Between SBP and EP,no significant difference in overall survival rate could be detected(P>0.05). But 5-year multiple myeloma-free survival rates were significantly different with 36.8%and 86.7%respectively(P=0.015). Conclusion:Radiotherapy can achieve excellent clinical effect for solitary plasmacytoma. Progression to multiple myeloma,especially in the case of SBP,remains to be addressed by further studies.