中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2014年
35期
6-9
,共4页
血液透析%血液透析滤过%血液灌流%维持性血液透析%微炎症状态%生存质量
血液透析%血液透析濾過%血液灌流%維持性血液透析%微炎癥狀態%生存質量
혈액투석%혈액투석려과%혈액관류%유지성혈액투석%미염증상태%생존질량
Hemodialysis%Hemodiafiltration%Hemoperfusion%Maintenance hemodialysis patient%Micro-inflammatory state%Quality of life
目的:研究不同血液净化方式对维持性血液透析患者微炎症状况及生存质量的影响。方法:选取东莞市人民医院血液净化室维持性血液透析患者75例,将患者随机分为三组:低通量血液透析(HD)组、血液透析滤过(HDF)组和血液透析联合血液灌流(HD+HP)组,连续治疗6个月后,检测治疗前后C反应蛋白(CRP)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、肿瘤坏死因子(TNF-α)及白蛋白(Ab)与血红蛋白(Hb)的含量,治疗前后进行两次SF-36问卷调查评估生存质量。结果:HDF组与HD+HP组治疗后CRP、IL-6、IL-8、TNF-α的清除及Ab与Hb上升均优于HD组(P<0.05),HDF组与HD+HP组两组间比较差异无统计学意义。治疗6个月前后三组患者行生存质量评分,在总体健康、躯体疼痛、躯体角色功能、社会功能、精力、心理健康方面,HDF组与HD+HP组治疗均优于HD组(P<0.05),HDF组与HD+HP组两组间比较差异无统计学意义,而情绪角色功能在治疗前后三组之间差异无统计学意义(P>0.05)。结论:维持血液透析患者存在微炎症状态,HD+HP及HDF能更好清除炎症因子,改善维持性血液透析患者微炎症状态,改善患者生存质量。
目的:研究不同血液淨化方式對維持性血液透析患者微炎癥狀況及生存質量的影響。方法:選取東莞市人民醫院血液淨化室維持性血液透析患者75例,將患者隨機分為三組:低通量血液透析(HD)組、血液透析濾過(HDF)組和血液透析聯閤血液灌流(HD+HP)組,連續治療6箇月後,檢測治療前後C反應蛋白(CRP)、白細胞介素-6(IL-6)、白細胞介素-8(IL-8)、腫瘤壞死因子(TNF-α)及白蛋白(Ab)與血紅蛋白(Hb)的含量,治療前後進行兩次SF-36問捲調查評估生存質量。結果:HDF組與HD+HP組治療後CRP、IL-6、IL-8、TNF-α的清除及Ab與Hb上升均優于HD組(P<0.05),HDF組與HD+HP組兩組間比較差異無統計學意義。治療6箇月前後三組患者行生存質量評分,在總體健康、軀體疼痛、軀體角色功能、社會功能、精力、心理健康方麵,HDF組與HD+HP組治療均優于HD組(P<0.05),HDF組與HD+HP組兩組間比較差異無統計學意義,而情緒角色功能在治療前後三組之間差異無統計學意義(P>0.05)。結論:維持血液透析患者存在微炎癥狀態,HD+HP及HDF能更好清除炎癥因子,改善維持性血液透析患者微炎癥狀態,改善患者生存質量。
목적:연구불동혈액정화방식대유지성혈액투석환자미염증상황급생존질량적영향。방법:선취동완시인민의원혈액정화실유지성혈액투석환자75례,장환자수궤분위삼조:저통량혈액투석(HD)조、혈액투석려과(HDF)조화혈액투석연합혈액관류(HD+HP)조,련속치료6개월후,검측치료전후C반응단백(CRP)、백세포개소-6(IL-6)、백세포개소-8(IL-8)、종류배사인자(TNF-α)급백단백(Ab)여혈홍단백(Hb)적함량,치료전후진행량차SF-36문권조사평고생존질량。결과:HDF조여HD+HP조치료후CRP、IL-6、IL-8、TNF-α적청제급Ab여Hb상승균우우HD조(P<0.05),HDF조여HD+HP조량조간비교차이무통계학의의。치료6개월전후삼조환자행생존질량평분,재총체건강、구체동통、구체각색공능、사회공능、정력、심리건강방면,HDF조여HD+HP조치료균우우HD조(P<0.05),HDF조여HD+HP조량조간비교차이무통계학의의,이정서각색공능재치료전후삼조지간차이무통계학의의(P>0.05)。결론:유지혈액투석환자존재미염증상태,HD+HP급HDF능경호청제염증인자,개선유지성혈액투석환자미염증상태,개선환자생존질량。
Objective:To investigate effect of different blood purification methods on micro-inflammatory state and the quality of life in maintenance hemodialysis patients.Method:A total of 75 MHD patients in the blood purification division of the dongguan people’s hospital were randomly divided into three groups:low flux hemodialysis group(HD group,n=25),hemodiafiltration group(HDF group,n=25)and hemodialysis combined hemoperfusion group(HD+HP group,n=25).The treatments lasted 6 months.The serum C-reactive protein(CRP),interleukin-6 (IL-6),interleukin-8(IL-8),tumor necrosis factor-α(TNF-α),hemoglobin(Hb)and serum albumin (ALB)were determined before and after the treatments in the there groups.The quality of life was evaluated using SF-36 questionaire.Result:After treatment,compared with HD groups,HDF group and HD+HP group had significantly lower levels of CRP,IL-6,IL-8,TNF-a,Ab and Hb were significantly better than before treatment(P<0.05),there were no difference between HDF group and HD+HP group.Total health condition,bodily pain,role-physical,social functioning,vitality and mental health in HDF group and HD+HP group were superior to those in HD group(P<0.05), there were no difference between HDF group and HD+HP group.But the difference was insignificant in role-emotional between three groups(P>0.05).Conclusion:Microinflammation state exists in MHD patients .HDF and HD+HP could had better effect than the HD on clearance of micro-inflammatory factor,may significantly improve the quality of life of MHD patients.