CAJ | 학술논문

近年来，抑癌基因Rap1GAP研究比较热门，研究发现Rap1GAP与肿瘤关系密切，在乳腺癌、结直肠癌、甲状腺癌、胰腺癌、宫颈癌等多种肿瘤中表达减低，并与疾病的发生、发展存在一定关系。作为抑癌基因下调的重要机制，Rap1GAP启动子甲基化越来越受到重视，其研究取得了一些进展，本文就Rap1GAP及其启动子甲基化与肿瘤的关系的研究进展作一综述。
근년래，억암기인Rap1GAP연구비교열문，연구발현Rap1GAP여종류관계밀절，재유선암、결직장암、갑상선암、이선암、궁경암등다충종류중표체감저，병여질병적발생、발전존재일정관계。작위억암기인하조적중요궤제，Rap1GAP계동자갑기화월래월수도중시，기연구취득료일사진전，본문취Rap1GAP급기계동자갑기화여종류적관계적연구진전작일종술。
In recent years, the study of tumor suppressor gene Rap1GAP is so hot. The study found that Rap1GAP which has close relationship with tumor, reduce the expression in breast cancer ,colorectal cancer, thyroid cancer, pancreatic cancer, cervical cancer and other tumors, and has some relationship with occurrence,and development of the disease. As an important mechanism for tumor suppressor genes down regulated Rap1GAP promoter methylation has been paid more and more attention, and the research has made more progress. This article reviews the research progress of the relationship between Rap1GAP and its promoter hypermethylation with tumor.